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T-TYPE CALCIUM CHANNEL MODULATORS COMPRISING AN AZASPIRONONANE CORE AND METHODS OF USE THEREOF
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T-TYPE CALCIUM CHANNEL MODULATORS COMPRISING AN AZASPIRONONANE CORE AND METHODS OF USE THEREOF
PCT NATIONAL PHASE APPLICATION
Published
Filed on 28 October 2024
Abstract
Disclosed herein are compounds for treating a condition modulated by calcium channel ion activity and pharmaceutical compositions comprising the compounds, wherein the compounds comprise an azaspirononane core and left- and right-hand substitutions of the azaspirononane core. Also disclosed herein are methods using the compounds to treat a disease or condition relating to aberrant function or activity of a T-type calcium channel.
Patent Information
| Application ID | 202447082172 |
| Invention Field | CHEMICAL |
| Date of Application | 28/10/2024 |
| Publication Number | 44/2024 |
Inventors
| Name | Address | Country | Nationality |
|---|---|---|---|
| LIRA, Ricardo | 12 Joshua Valley Road East Lyme, CT 06333 | U.S.A. | U.S.A. |
| TOOP, Hamish | C/o Praxis Precision Medicines, Inc. 99 High Street, 30th Floor Boston, MA 02110 | U.S.A. | U.S.A. |
| GRIFFIN, Andrew, Mark | 32 Rue Barette L'Île-Bizard Montreal, QC H9C 2Y7 | Canada | Canada |
| SUTTON, Jon | C/o Charles River 8-9 The Spire Green Centre Harlow, Essex CM19 5TR | U.K. | U.K. |
| MILANOS, Lampros | C/o Charles River Chesterford Research Park Saffron Walden CB10 1XL | U.K. | U.K. |
| CRUMPLER, Simon | C/o Charles River 8-9 The Spire Green Centre Harlow, Essex CM19 5TR | U.K. | U.K. |
Applicants
| Name | Address | Country | Nationality |
|---|---|---|---|
| PRAXIS PRECISION MEDICINES, INC. | 99 High Street, 30th Floor Boston, MA 02110 | U.S.A. | U.S.A. |
Documents
| Name | Date |
|---|---|
| 202447082172-COMPLETE SPECIFICATION [28-10-2024(online)].pdf | 28/10/2024 |
| 202447082172-DECLARATION OF INVENTORSHIP (FORM 5) [28-10-2024(online)].pdf | 28/10/2024 |
| 202447082172-FORM 1 [28-10-2024(online)].pdf | 28/10/2024 |
| 202447082172-FORM 18 [28-10-2024(online)].pdf | 28/10/2024 |
| 202447082172-PRIORITY DOCUMENTS [28-10-2024(online)].pdf | 28/10/2024 |
| 202447082172-PROOF OF RIGHT [28-10-2024(online)].pdf | 28/10/2024 |
| 202447082172-REQUEST FOR EXAMINATION (FORM-18) [28-10-2024(online)].pdf | 28/10/2024 |
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