STEM CELL ASSISTED NEURAL HEALING IN PARALYZED PATIENTS

Abstract

ABSTRACT “STEM CELL ASSISTED NEURAL HEALING IN PARALYZED PATIENTS” The present invention provides a method for stem cell-assisted neural healing to treat paralysis by regenerating damaged nerves. The process begins with precise nerve identification through diagnostic imaging and neurosensory evaluations. Damaged nerve fibrils are destroyed using radiofrequency ablation (RFA), while 3D electro spun scaffolds guide axonal regrowth and prevent misdirected nerve regeneration. Stem cells, harvested from the patient, are implanted at the injury site within the spinal cord to stimulate natural nerve repair. Nerve growth factors such as NGF, GGF, and FGF are applied to accelerate recovery, along with electrical stimulation to speed up axonal regeneration. The method provides a permanent, cost-effective treatment with no need for external devices, reducing the risk of complications and offering improved outcomes for paralyzed patients. Supplements like vitamin B12 and folic acid further support nerve function during recovery. Figure 2

Specification

Description:TECHNICAL FIELD
[0001] The present invention relates to the field of medical science, and more particularly, the present invention relates to the Stem cell assisted neural healing in paralyzed patients.
BACKGROUND ART
[0002] The following discussion of the background of the invention is intended to facilitate an understanding of the present invention. However, it should be appreciated that the discussion is not an acknowledgment or admission that any of the material referred to was published, known, or part of the common general knowledge in any jurisdiction as of the application's priority date. The details provided herein the background if belongs to any publication is taken only as a reference for describing the problems, in general terminologies or principles or both of science and technology in the associated prior art.
[0003] Paralysis is said to happen when one is unable to make voluntary muscle movements. Around 5.4 million people worldwide have some form of paralysis. There can be various causes behind this to mention some common ones are Strokes, Spinal Cord Injury, Nerve Disorders such as Multiple Sclerosis, Guillain Barre Syndrome, Brain Injury such as Cerebral Palsy, Amyotropic Lateral Sclerosis, Birth defects such as Spina Bifida. Some people experience temporary paralysis and regain partial or full movement over time. For e.g. Bell's Palsy temporarily paralyzes facial muscle.
[0004] Paralysis can range from:
- Partial (Paresis) - The person can control some but not all muscle
- Complete - The person has no control over muscles
[0005] It can either be:
- Flaccid - Muscles get flabby and shrink
- Spastic - Muscles get tighten, jerks, and spasms
[0006] It can further be classified into:
- Diplegia - Same area on both sides are affected
- Hemiplegia - One side of the body is affected
- Monoplegia - One limb is affected
- Paraplegia - Both hands/legs are affected
- Quadriplegia - All the four limbs are affected
[0007] There isn't a cure for permanent paralysis. Spinal cord can't heal itself. Learning to live with paralysis is challenging. Physical, occupational and speech therapy can accommodate paralysis and provide exercises, adaptive and assistive devices to improve function.
- Adaptive Equipment - allows one to feed or drive
- Assistive Equipment - wheelchair
- Orthotic/ Prosthetic devices - braces
- Voice Activated Technology - computers, phones.
[0008] The various Nerve Surgeries available are: Nerve Repair, Nerve Graft, Nerve Transfer, Neurolysis - Involves removing the scar tissue. The Pathophysiology behind Nerve Injury are: Crush Injuries, Iatrogenic Injuries (traction or thermal injury), Penetrating Injuries (Stretch/Transect). Nerve Injury is further classified under:
- SELDON SCALE:
- Neurapraxia - A localized conduction block with focal demyelination and no Wallerian Degeneration. Complete recovery is expected.
- Axonotmesis - Variable amount of Axonal Injury with Wallerian Degeneration and an intact epineurium. Synkinesis may occur in more severe cases.
- Neurotmesis - Complete nerve transection with Wallerian Degeneration. Flaccidity will persist unless the nerve is repaired.
[0009] Other modalities of treatment include:
- Since nerve injury is related to pain, Giving Pain killers such as NSAIDS, Corticosteroids.
- Giving Antidepressants
- Cryotherapy
- Physiologic Therapies - Tran's cutaneous electric nerve stimulation and Low level laser therapy.
[0010] In light of the foregoing, there is a need for Stem cell assisted neural healing in paralyzed patients that overcomes problems prevalent in the prior art associated with the traditionally available method or system, of the above-mentioned inventions that can be used with the presented disclosed technique with or without modification.
[0011] All publications herein are incorporated by reference to the same extent as if each individual publication or patent application were specifically and individually indicated to be incorporated by reference. Where a definition or use of a term in an incorporated reference is inconsistent or contrary to the definition of that term provided herein, the definition of that term provided herein applies, and the definition of that term in the reference does not apply.
OBJECTS OF THE INVENTION
[0012] The principal object of the present invention is to overcome the disadvantages of the prior art by providing Stem cell assisted neural healing in paralyzed patients.
[0013] Another object of the present invention is to provide Stem cell assisted neural healing in paralyzed patients that is a permanent treatment.
[0014] Another object of the present invention is to provide Stem cell assisted neural healing in paralyzed patients, wherein the Patient is free of carrying any burden.
[0015] Another object of the present invention is to provide Stem cell assisted neural healing in paralyzed patients that, Since there is no device or equipment left behind there is no associated electrical or any other sort of accidents.
[0016] Another object of the present invention is to provide Stem cell assisted neural healing in paralyzed patients that Cost effective since it will be a one-time procedure.
[0017] Another object of the present invention is to provide Stem cell assisted neural healing in paralyzed patients that has no long-term side effects.
[0018] The foregoing and other objects of the present invention will become readily apparent upon further review of the following detailed description of the embodiments as illustrated in the accompanying drawings.
SUMMARY OF THE INVENTION
[0019] The present invention relates to Stem cell assisted neural healing in paralyzed patients.
[0020] Nerve injuries can worsen over time if not addressed promptly. Early administration of NSAIDs or corticosteroids can help manage pain, even as a preventive approach. Surgical intervention is crucial within 3 months post-injury, before Wallerian degeneration begins. To assess the extent of paralysis, various tests are required, including 2D imaging (periapical radiography), 3D imaging (CBCT), neurosensory evaluations, mechanoceptive tests (static light touch and two-point discrimination), nociceptive tests (thermal discrimination), myelograms (to assess spinal cord injuries), and nerve biopsies to detect Wallerian degeneration or neurotmesis.
[0021] For precise nerve path identification, a physical exam, nerve conduction study, electromyography, and MR neurography are performed. Radiofrequency ablation (RFA) is used to destroy damaged nerve fibrils while preserving the epineurium. Simultaneously, 3D electrospun scaffolds guide nerve regeneration and prevent misdirected growth. Stem cells, nerve growth factors (NGF, GGF, FGF, GDNF), and electrical fields accelerate nerve repair, alongside supplements like vitamin B12 and folic acid.
[0022] While the invention has been described and shown with reference to the preferred embodiment, it will be apparent that variations might be possible that would fall within the scope of the present invention.
BRIEF DESCRIPTION OF DRAWINGS
[0023] So that the manner in which the above-recited features of the present invention can be understood in detail, a more particular description of the invention, briefly summarized above, may have been referred by embodiments, some of which are illustrated in the appended drawings. It is to be noted, however, that the appended drawings illustrate only typical embodiments of this invention and are therefore not to be considered limiting of its scope, for the invention may admit to other equally effective embodiments.
[0024] These and other features, benefits, and advantages of the present invention will become apparent by reference to the following text figure, with like reference numbers referring to like structures across the views, wherein:
[0025] Fig.1 Normal neuron;
[0026] Fig.2 Neuronal path tracing by MR neurography1;
[0027] Fig.3 Radiofrequency ablation of a nerve; and
[0028] Fig. 4 3D fibrous Electrospun 3D scaffolds3.
DETAILED DESCRIPTION OF THE INVENTION
[0029] While the present invention is described herein by way of example using embodiments and illustrative drawings, those skilled in the art will recognize that the invention is not limited to the embodiments of drawing or drawings described and are not intended to represent the scale of the various components. Further, some components that may form a part of the invention may not be illustrated in certain figures, for ease of illustration, and such omissions do not limit the embodiments outlined in any way. It should be understood that the drawings and the detailed description thereto are not intended to limit the invention to the particular form disclosed, but on the contrary, the invention is to cover all modifications, equivalents, and alternatives falling within the scope of the present invention as defined by the appended claim.
[0030] As used throughout this description, the word "may" is used in a permissive sense (i.e. meaning having the potential to), rather than the mandatory sense, (i.e. meaning must). Further, the words "a" or "an" mean "at least one" and the word "plurality" means "one or more" unless otherwise mentioned. Furthermore, the terminology and phraseology used herein are solely used for descriptive purposes and should not be construed as limiting in scope. Language such as "including," "comprising," "having," "containing," or "involving," and variations thereof, is intended to be broad and encompass the subject matter listed thereafter, equivalents, and additional subject matter not recited, and is not intended to exclude other additives, components, integers, or steps. Likewise, the term "comprising" is considered synonymous with the terms "including" or "containing" for applicable legal purposes. Any discussion of documents, acts, materials, devices, articles, and the like are included in the specification solely for the purpose of providing a context for the present invention. It is not suggested or represented that any or all these matters form part of the prior art base or were common general knowledge in the field relevant to the present invention.
[0031] In this disclosure, whenever a composition or an element or a group of elements is preceded with the transitional phrase "comprising", it is understood that we also contemplate the same composition, element, or group of elements with transitional phrases "consisting of", "consisting", "selected from the group of consisting of, "including", or "is" preceding the recitation of the composition, element or group of elements and vice versa.
[0032] The present invention is described hereinafter by various embodiments with reference to the accompanying drawing, wherein reference numerals used in the accompanying drawing correspond to the like elements throughout the description. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiment set forth herein. Rather, the embodiment is provided so that this disclosure will be thorough and complete and will fully convey the scope of the invention to those skilled in the art. In the following detailed description, numeric values and ranges are provided for various aspects of the implementations described. These values and ranges are to be treated as examples only and are not intended to limit the scope of the claims. In addition, several materials are identified as suitable for various facets of the implementations. These materials are to be treated as exemplary and are not intended to limit the scope of the invention.
[0033] The present invention relates to Stem cell assisted neural healing in paralyzed patients.
[0034] The process begins with a comprehensive diagnosis using 2D and 3D imaging (e.g., CBCT), neurosensory evaluation, nerve conduction studies, electromyography, and MR neurography to locate the damaged nerve. The damaged nerve fibrils are selectively destroyed using radiofrequency ablation (RFA) while preserving the epineurium. This creates a hollow channel that extends to the nerve cell body within the spinal cord.
[0035] Simultaneously, a 3D fibrous electrospun scaffold is introduced to guide directed nerve regrowth and prevent misdirected axonal regeneration. Stem cells harvested from the patient are implanted at the injury site to enhance nerve repair and promote natural healing. To accelerate this process, nerve growth factors such as NGF, GGF, FGF, GDNF, and NT3 are applied to the nerve conduits, encouraging regeneration. The application of electrical fields or gradients speeds up axonal regeneration, while supplements like vitamin B12 and folic acid support nerve function.
[0036] The invention offers a permanent solution to paralysis without the need for external devices or long-term electrical equipment, making it cost-effective and low-risk compared to existing treatments.
[0037] Various modifications to these embodiments are apparent to those skilled in the art from the description and the accompanying drawings. The principles associated with the various embodiments described herein may be applied to other embodiments. Therefore, the description is not intended to be limited to the 5 embodiments shown along with the accompanying drawings but is to be providing the broadest scope consistent with the principles and the novel and inventive features disclosed or suggested herein. Accordingly, the invention is anticipated to hold on to all other such alternatives, modifications, and variations that fall within the scope of the present invention and appended claims.
, Claims:CLAIMS
We Claim:
1) A method for treating paralysis in patients using stem cell-assisted neural healing, the method comprising the steps of:
identifying the affected nerve through diagnostic procedures including 2D and 3D imaging, neurosensory evaluations, nerve conduction studies, electromyography, and MR neurography,
destroying damaged nerve fibrils using radiofrequency ablation (RFA) while preserving the epineurium,
creating a hollow channel extending to the nerve cell body,
introducing 3D electrospun scaffolds to guide nerve regeneration and prevent misdirected axonal growth,
implanting harvested stem cells at the site of the injured nerve within the spinal cord to promote nerve regeneration,
applying nerve growth factors including NGF, GGF, FGF, GDNF, and NT3 to stimulate nerve repair,
applying electrical fields or gradients across the damaged nerve to accelerate axonal regeneration.
2) The method as claimed in claim 1, wherein the stem cells used for nerve regeneration are harvested in vitro from the patient and implanted at the site of injury to enhance compatibility and reduce the risk of rejection.
3) The method as claimed in claim 1, wherein the scaffolding used is composed of 3D fibrous electrospun materials, designed to promote directed nerve growth while preventing the misdirection of regenerating axons, thus improving functional recovery.
4) The method as claimed in claim 1, wherein the method further comprising the administration of neurotropic factors including Ciliary Neurotropic Factors, Leupeptin, and other growth-promoting agents to the nerve conduits to enhance the natural regenerative capacity of the damaged nerve.
5) The method as claimed in claim 1, wherein the radiofrequency ablation (RFA) is used to selectively destroy damaged nerve fibrils while keeping the surrounding epineurium intact, creating a stable environment for the implanted stem cells to proliferate and support nerve regrowth.
6) A method for treating spinal cord injuries in paralyzed patients, involving the steps of:
tracing the damaged nerve path using MR neurography,
performing radiofrequency ablation to destroy the damaged nerve,
placing 3D scaffolds at the injury site to guide regenerating axons,
implanting stem cells at the precise location of the injury within the spinal cord,
using nerve growth factors and electrical stimulation to enhance axonal regeneration and neural connectivity.
7) A nerve repair system using stem cell-assisted neural regeneration for treating paralysis, the system comprising:
an imaging and diagnostic module for identifying nerve damage,
a radiofrequency ablation system for selective nerve destruction,
3D electrospun scaffolds for guiding axonal regeneration,
a stem cell implantation procedure, and
a nerve growth factor delivery system to accelerate nerve recovery.

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