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SNCA-TARGETING SIRNA COMPOSITIONS FOR TREATING SNCA-ASSOCIATED DISEASE
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SNCA-TARGETING SIRNA COMPOSITIONS FOR TREATING SNCA-ASSOCIATED DISEASE
PCT NATIONAL PHASE APPLICATION
Published
Filed on 1 November 2024
Abstract
The disclosure relates to double stranded ribonucleic acid (dsRNAi) agents and compositions targeting a SNCA gene, particularly in a CNS tissue, as well as methods of inhibiting expression of a SNCA gene and methods of treating subjects having a SNCA-associated neurodegenerative disease or disorder, e.g., Parkinson's Disease (PD), multiple system atrophy (MSA), Lewy body dementia (LBD), among other synucleinopathies, using such dsRNAi agents and compositions.
Patent Information
| Application ID | 202447083688 |
| Invention Field | BIOTECHNOLOGY |
| Date of Application | 01/11/2024 |
| Publication Number | 45/2024 |
Inventors
| Name | Address | Country | Nationality |
|---|---|---|---|
| HOANG DANG, Lan Thi | 675 West Kendall Street Henri A. Termeer Square Cambridge, Massachusetts 02142 | U.S.A. | U.S.A. |
| SCHLEGEL, Mark K. | 675 West Kendall Street Henri A. Termeer Square Cambridge, Massachusetts 02142 | U.S.A. | U.S.A. |
| BARRY, Joseph | 675 West Kendall Street Henri A. Termeer Square Cambridge, Massachusetts 02142 | U.S.A. | U.S.A. |
| NGUYEN, Tuyen | 675 West Kendall Street Henri A. Termeer Square Cambridge, Massachusetts 02142 | U.S.A. | U.S.A. |
| CASTORENO, Adam | 675 West Kendall Street Henri A. Termeer Square Cambridge, Massachusetts 02142 | U.S.A. | U.S.A. |
| SO, Kawai | 675 West Kendall Street Henri A. Termeer Square Cambridge, Massachusetts 02142 | U.S.A. | U.S.A. |
Applicants
| Name | Address | Country | Nationality |
|---|---|---|---|
| ALNYLAM PHARMACEUTICALS, INC. | 675 West Kendall Street Henri A. Termeer Square Cambridge, Massachusetts 02142 | U.S.A. | U.S.A. |
Documents
| Name | Date |
|---|---|
| 202447083688-CLAIMS UNDER RULE 1 (PROVISIO) OF RULE 20 [01-11-2024(online)].pdf | 01/11/2024 |
| 202447083688-COMPLETE SPECIFICATION [01-11-2024(online)].pdf | 01/11/2024 |
| 202447083688-DECLARATION OF INVENTORSHIP (FORM 5) [01-11-2024(online)].pdf | 01/11/2024 |
| 202447083688-DRAWINGS [01-11-2024(online)].pdf | 01/11/2024 |
| 202447083688-FIGURE OF ABSTRACT [01-11-2024(online)].pdf | 01/11/2024 |
| 202447083688-FORM 1 [01-11-2024(online)].pdf | 01/11/2024 |
| 202447083688-FORM 18 [01-11-2024(online)].pdf | 01/11/2024 |
| 202447083688-POWER OF AUTHORITY [01-11-2024(online)].pdf | 01/11/2024 |
| 202447083688-Sequence Listing in PDF [01-11-2024(online)].pdf | 01/11/2024 |
| 202447083688-Sequence Listing in txt [01-11-2024(online)].txt | 01/11/2024 |
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