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P97-BASE PROTAC ANTIBODY CONJUGATES AND METHODS OF USE
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P97-BASE PROTAC ANTIBODY CONJUGATES AND METHODS OF USE
PCT NATIONAL PHASE APPLICATION
Published
Filed on 31 October 2024
Abstract
New system to facilitate the degradation of target proteins within cells, which uses a chimeric protein with a moiety of single-domain VHH antibodies fused with the UBX domain that is recognized by p97. Where the VHH binds proteins selectively and the UBX domain recruit the protein for p97- mediated degradation based of proteasome activity. Single-domain VHH antibodies, or Nanobody (Nb) can be attached to UBX directly or using a linker.
Patent Information
| Application ID | 202427083612 |
| Invention Field | CHEMICAL |
| Date of Application | 31/10/2024 |
| Publication Number | 49/2024 |
Inventors
| Name | Address | Country | Nationality |
|---|---|---|---|
| ROJAS-FERNANDEZ, Alejandro | Las Encinas 220 Valdivia, 5110033 | Chile | Chile |
| SALINAS, Constanza | Las Encinas 220 Valdivia, 5110033 | Chile | Chile |
Applicants
| Name | Address | Country | Nationality |
|---|---|---|---|
| UNIVERSIDAD AUSTRAL DE CHILE | Independencia 631 Valdivia, 5110566 | Chile | Chile |
Documents
| Name | Date |
|---|---|
| Abstract1.jpg | 02/12/2024 |
| 202427083612-CLAIMS UNDER RULE 1 (PROVISIO) OF RULE 20 [31-10-2024(online)].pdf | 31/10/2024 |
| 202427083612-COMPLETE SPECIFICATION [31-10-2024(online)].pdf | 31/10/2024 |
| 202427083612-DECLARATION OF INVENTORSHIP (FORM 5) [31-10-2024(online)].pdf | 31/10/2024 |
| 202427083612-DRAWINGS [31-10-2024(online)].pdf | 31/10/2024 |
| 202427083612-FIGURE OF ABSTRACT [31-10-2024(online)].pdf | 31/10/2024 |
| 202427083612-FORM 1 [31-10-2024(online)].pdf | 31/10/2024 |
| 202427083612-FORM 18 [31-10-2024(online)].pdf | 31/10/2024 |
| 202427083612-PRIORITY DOCUMENTS [31-10-2024(online)].pdf | 31/10/2024 |
| 202427083612-REQUEST FOR EXAMINATION (FORM-18) [31-10-2024(online)].pdf | 31/10/2024 |
| 202427083612-Sequence Listing in PDF [31-10-2024(online)].pdf | 31/10/2024 |
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