NOVEL TITANIUM COATING WITH FUCOIDAN LOADED WITH AZITHROMYCIN

Abstract

ABSTRACT : Titanium implants are widely used in dental surgeries due to their excellent biocompatibility and mechanical properties. However, implant-associated infections lemain d significant concern. The present invention relates to a novel titanium coating formulation that integrates fucoidan and azithromycin to enhance antimicrobial efficacy for biomedical applications. This innovative coating addresses the growing need for effective surface modifications in implants to reduce infection rates. Fucoidan, a bioactive polysaccharide derived from brown seaweed, exhibits natural antimicrobial and anti-inflammatory properties, while azithromycin, a broad-spectrum antibiotic, offers potent antibacterial activity. The combination of these two components in a titanium coating not only promotes biocompatibility but also provides a sustained release mechanism for azithromycin, thereby ensuring prolonged antimicrobial action. This formulation demonstrates significant potential in improving the longevity and safety of medical implants, ultimately reducing the risk of postoperative infections and enhancing patient outcomes. The invention is suitable for various applications, including orthopedic implants, cardiovascular stents other than dental applications .

Specification

FORM - 2
THE PATENTS ACT, 1970
(39 OF 1970)
&
THE PATENTS RULES, 2003
COMPLETE SPECIFICATION
(see Section 10 & rule 13)

1. TITLE OF THE INVENTION: : Novel titanium coating with Fucoidan loaded with Azithromycin .
2. APPLICANT:
S.No NAME NATIONALITY ADDRESS
1 Saveetha Institute of Medical
and Technical Sciences
INDIAN
No: 162, Poonamallee High
Road, Velappanchavadi,
Chennai-600077

3. PREAMBLE TO THE DESCRIPTION:
The following specification describes the invention and how it is to be performed.

Bank : INDUSIND BANK
Branch : NUNGAMBAKKAM
( SAVEETHA UNIVERSITY )
DD No : 402483
DD Date: 19/10/2024
DDAmount: 8900/-

TITLE OF INVENTION :
Novel Titanium Coating with Fucoidan loaded with Azithromycin.

FIELD OF INVENTION :
The invention relates to suitable titanium coating for enhanced antimicrobial properties.

BACKGROUND:
Dental implants have surged in popularity over recent years as an effective and long-lasting solution for tooth replacement. Patients increasingly choose implants due to their ability to provide a natural-looking and functional alternative to traditional dentures and bridges. The advantages of dental implants include improved stability, enhanced chewing efficiency, and preservation of jawbone health, which prevents the bone loss often associated with missing teeth.

Furthermore, their high success rates and low maintenance requirements appeal to individuals seeking a reliable long-term option. With ongoing
advancements in dental technology and growing awareness of their benefits, dental implants have become a preferred choice for restoring smiles, enhancing quality of life, and boosting confidence in patients worldwide.

Despite their popularity and success, dental implants can still present various problems and complications. Titanium and titanium alloys are
widely used in dental implants. Both are vulnerable to infection, due to biofilm formation on the surface and compromised immune capacity at
the implant/tissue interface. That is why it is extremely important to maintain bone tissue in an aseptic environment during and after implantation. This moment is the riskiest time for infection because the local defense mechanism is seriously disrupted by surgical injuries.

In fact, the most frequent cause of early implant failure is infection following bacterial contamination of the surgical site. Studies suggest that the incidence of postoperative infections around dental implants ranges from 1% to 10%, depending on various factors such as patient health, surgical technique, and oral hygiene practices, postoperative infections
after implant placement can affect up to 2.4% of the implants.

Focusing on avoiding and controlling bacterial adhesion, there are different approaches to develop a Ti surface that delivers drugs exerting
antimicrobial activity. One of the common drug delivery systems (DDs)to prevent infections is the use of coated titanium implant.

Fucoidan loaded with azithromycin demonstrates potential as a novel coating material for titanium implants, offering enhanced antimicrobial
properties and biocompatibility.

This titanium coating underscores the feasibility of leveraging natural polymers for controlled drug delivery systems to improve the safety and
efficacy of biomedical implants.

SUMMARY OF INVENTION :
Fucoidan, a sulfated polysaccharide extracted from brown seaweed, has emerged as a promising material for dental implant coatings due to its numerous beneficial properties. Its natural biocompatibility makes it an ideal candidate for enhancing the integration of implants with surrounding bone and soft tissues. The application of fucoidan as a coating can significantly improve the biological response of dental implants in several ways due to its antibacterial and anti-inflammatory effects by mitigating inflammatory responses around the implant site, promoting better healing and tissue integration.

In vitro antibacterial tests of our novel titanium coating with the combination of azithromycin with PVA-Fucoidan-Titanium are effective. PVA-Fucoidan-Titanium alone also shows some antibacterial activity, though less potent than azithromycin

When combined with antimicrobial agents like azithromycin, fucoidan can facilitate a controlled release mechanism, The invitro data suggests a
sustained-release profile where Azithromycin is released gradually over time rather than all at once, providing prolonged antimicrobial protection
and reducing the need for systemic antibiotics.

Furthermore the presence of fucoidan and addition of azithromycin enhances the hydrophilicity of the PVA-fucoidan composite and increases the roughness of the titanium surface thereby enhancing
osteoconductivity, encouraging bone cell proliferation and differentiation, thereby improving osseointegration and stabilizing the implant.

CLAIMS OF THE INVENTION :

1. A dental implant coated with a composition comprising fucoidan and azithromycin, wherein the coating enhances antimicrobial properties and promotes osseointegration.

2. The fucoidan is derived from brown seaweed and possesses antiinflammatory properties and excellent biocompatibility as it's a naturally occurring.

3. The azithromycin is embedded in the coating to provide a sustained release for prolonged antimicrobial action.

4. A method for fabricating a dental implant coating that incorporates fucoidan and azithromycin to enhance the biocompatibility and
antimicrobial efficacy of the implant.

5. The coating exhibits a reduction in the incidence of postoperative infections compared to uncoated implants.

6. The coating has been shown to enhance patient outcomes through improved healing rates and reduced inflammatory responses.

REFERENCES :
28-Oct-2024/130779/202441082184/Form 2(Title Page)
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