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MULTICOMPONENT SYSTEMS FOR SITE-SPECIFIC GENOME MODIFICATIONS

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MULTICOMPONENT SYSTEMS FOR SITE-SPECIFIC GENOME MODIFICATIONS

PCT NATIONAL PHASE APPLICATION

Published

date

Filed on 25 November 2024

Abstract

The invention includes systems, compositions, and. methods for the making of modular gene editing through reverse transcriptase related processes. Systems and methods that use modified nucleotides and peptides are specifically provided. Transgene introduction into eukaryotic genomes offers vast opportunities to improve, correct and/or alter genetic expression, and concomitantly serve to treat or ameliorate disease symptoms. Successful transgene insertion would allow for rescue from loss-of-function mutations, inhibition of gain-of-function mutations, the exogenous control of RNA and/or protein expression, the introduction of isoform expression specificity, engineered gene and protein expression, and other useful outcomes.

Patent Information

Application ID202437091617
Invention FieldBIO-CHEMISTRY
Date of Application25/11/2024
Publication Number48/2024

Inventors

NameAddressCountryNationality
COLLINS, Kathleen2150 Shattuck Ave., Suite 510 Berkeley, California 94704U.S.A.U.S.A.
ZHANG, Ziaozhu2150 Shattuck Ave., Suite 510 Berkeley, California 94704U.S.A.U.S.A.
VAN TREECK, Briana2150 Shattuck Ave., Suite 510 Berkeley, California 94704U.S.A.U.S.A.
UPTON, Heather E.2150 Shattuck Ave., Suite 510 Berkeley, California 94704U.S.A.U.S.A.
PALM, Sarah2150 Shattuck Ave., Suite 510 Berkeley, California 94704U.S.A.U.S.A.
MCINTYRE, Jeremy2150 Shattuck Ave., Suite 510 Berkeley, California 94704U.S.A.U.S.A.

Applicants

NameAddressCountryNationality
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA1111 Franklin Street, 12th Floor Oakland, California 94607U.S.A.U.S.A.

Documents

NameDate
202437091617-Proof of Right [27-11-2024(online)].pdf27/11/2024
202437091617-DECLARATION OF INVENTORSHIP (FORM 5) [25-11-2024(online)].pdf25/11/2024
202437091617-DRAWINGS [25-11-2024(online)].pdf25/11/2024
202437091617-EVIDENCE FOR REGISTRATION UNDER SSI(FORM-28) [25-11-2024(online)].pdf25/11/2024
202437091617-FORM 1 [25-11-2024(online)].pdf25/11/2024
202437091617-FORM 18 [25-11-2024(online)].pdf25/11/2024
202437091617-FORM FOR SMALL ENTITY(FORM-28) [25-11-2024(online)].pdf25/11/2024
202437091617-POWER OF AUTHORITY [25-11-2024(online)].pdf25/11/2024
202437091617-PRIORITY DOCUMENTS [25-11-2024(online)].pdf25/11/2024
202437091617-REQUEST FOR EXAMINATION (FORM-18) [25-11-2024(online)].pdf25/11/2024
202437091617-Sequence Listing in PDF [25-11-2024(online)].pdf25/11/2024

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