MOISTURIZING FORMULATION AND METHOD OF PREPARATION THEREOF

Abstract

The present invention relates to the moisturizing composition and method of preparation of the same, wherein the formulation is focussed on targeting dry skin, scaling and specifically to psoriasis. The moisturizing formulation comprises 3 phases within , wherein the phase A includes water, silica , propanediol , xanthan gum in the ratio of 80.7, 2.50, 5 and 0.5% w/v respectively; the phase B, including stearic acid, squalane, cetyl alcohol, salicylic acid in the ratio of 2,2,1.5,1 % w/v respectively and Phase C, including banana leaf extract, Momordica charantia leaf extract, Stellaria media leaf extract, marjoram extract, wrightia tinctoria extract, acalypha indica extract along with Ph adjuster (triethanolamine) in the ratio of 2,0.5,0.5,0.5,0.5,0.5,0.3 respectively. Fig 1

Specification

Description:FIELD OF THE INVNETION
The present invention relates to a formulation of a moisturizing formulation and its method of preparation. The present invention specifically relates to moisturizing formulation specifically targeting psoriasis wherein the present moisturizing formulation effectively targets in reducing and relieving both dryness and associated itch - scratch cycle.
BACKGROUND OF THE INVENTION
The skin is one of the most important organs of the body. Skin comes into contact with the rest of the world. It holds body fluids in, preventing dehydration and keeps harmful microbes out. Skin includes nerve endings that help you feel things like heat, cold, and pain. It provides several functions to our body, it provides a protective barrier against mechanical, thermal and physical injury and hazardous substances, prevents loss of moisture, reduces harmful effects of UV radiation, acts as a sensory organ (touch, detects temperature), helps regulate temperature and importantly an immune organ to detect infections etc.
Skin can be attacked by several organisms or pathogens which result in skin diseases. Pathogens that cause infectious diseases are viruses, bacteria, fungi, parasites and, rarely, prions. You can get infectious diseases from other people, bug bites and contaminated food, water or soil. One of the skin disease the present invention focusses on working on is Psoriasis, a condition in which skin cells build up and form scales and itchy, dry patches. Psoriasis is thought to be an immune system problem. Triggers include infections, stress and cold. The most common symptom is thick skin patches typically seen on elbows, knees, and lower back associated with white scaling on the scalp. Treatment aims to remove scales and stop skin cells from growing so quickly. Topical ointments, light therapy and medication can offer relief.
Several prior arts have focussed on identifying relief and cure to this skin conditions and its effects of dry skin and scaling like the prior art US2007161525A2 titled as "Skin Care Moisturizing formulation Composition" discusses a skin care moisturizing composition that quickly provides relief from the visual appearance of dry skin, particularly the ashen appearance of darker complexioned individuals.
The invention further comprises a moisturizing composition that provides intermediate term, long term, and continuous relief of dry skin and its attendant symptoms. The moisturizing composition comprises a protease enzyme that facilitates the digestion of corneodesmosomal linkages between skin corneocyte cells.
Another patent application US2018049971A2 titled as "Multi-Purpose Moisturizing Composition" discusses a multi-purpose moisturizing formulation . In one embodiment, the multi-purpose moisturizing formulation has the form of a cream and is composed of a plurality of butter compounds such as, for example, rhea butter, cocoa butter, and jojoba butter, combined with a plurality of essential oils such as, for example, sweet almond oil, castor oil, argan oil, coconut oil, grape seed oil, and the like.
In another embodiment, the multi-purpose moisturizing formulation has the form of an oil and is composed of a plurality of essential oils such as, for example, hemp seed oil, vitamin E oil, chamomile oil, and the like. The cream or the oil embodiments of the multi-purpose moisturizing formulation may be applied to an area of dry skin in order to alleviate itching and irritation while returning the skin to a healthy moisture level.
Yet another patent application US2006008453A2 titled as "Methods And Compositions For Preventing And Treating Sensitive And Dry Skin" discusses a composition(s) for preventing and/or treating sensitive and/or dry skin include at least an effective amount of at least one agent and at least an effective amount of at least one divalent inorganic cation, wherein the at least one agent includes at least one member selected from the group consisting of at least one microorganism, a fraction of the at least one microorganism and a metabolite of the at least one microorganism. Methods for preparing such compositions and cosmetic treatment methods employing such compositions are also provided.
OBJECTIVE OF THE INVENTION
The primary objective of the present invention is to provide a moisturizing composition and its method of preparation to relieve dryness and itchiness
Also the objective of the present invention is to provide a moisturizing composition and its method of preparation to relieve Psoriasis and its associated symptoms and provide a first line of defence.
It is another objective of the invention to provide a moisturizing composition and method of preparation for skin hydration and strengthening barrier.
SUMMARY OF THE INVENTION
The present invention relates to the moisturizing composition focussed on targeting dry skin, scaling and specifically to psoriasis. The moisturizing formulation comprises 3 phases within , wherein
 The phase A includes water, silica , propanediol , xanthan gum in the ratio of 80.7, 2.50, 5 and 0.5% w/v respectively;
 The phase B, including stearic acid, squalane, cetyl alcohol, salicylic acid in the ratio of 2,2,1.5,1 % w/v respectively and
 Phase C, including banana leaf extract, Momordica charantia leaf extract, Stellaria media leaf extract, marjoram extract, wrightia tinctoria extract, acalypha indica extract along with Ph adjuster ( in the present formulation the Ph adjuster is triethanolamine) in the ratio of 2,0.5,0.5,0.5,0.5,0.5,0.3 respectively.
 The method of preparation of moisturizing formulation comprises steps of :
a) Preparation of Phase A, by mixing the required amounts of silica with water and add the prefix of proanediol at a temperature of 75 deg Centrigrade,
b) Preparation of phase B, by mixing the required amounts of stearic acid, squalane , cetyl alcohol and salicylic acid at the temperature 75 deg Centrigrade,
c) Preparation of Phase C, by mixing banana leaf extract, Momordica charantia leaf extract, Stellaria media leaf extract, marjoram extract, wrightia tinctoria extract, acalypha indica extract and adjusting the pH to 4.0 using pH adjuster triethanolamine.
d) The herbal elements are extracted in two steps
i. sundry all the herbs under sunlight for 3 weeks and
ii. infuse the herbs in olive oil and sundry for at least 36 hours
The present formulation is presented in various embodiments like soap, shampoo, moisturizer, oil etc.
BRIEF DESCRIPTION OF FIGURES
Other features and advantages of the present invention will become apparent from the detailed description of the invention which follows, when considered in light of the accompanying drawings in which:
FIG 1 Illustrates the method of preparation of the moisturizing formulation
DETAILED DESCRIPTION
Psoriasis is a chronic immune-mediated inflammatory skin disease with multiple phenotypically distinct subtypes. eg plaque, flexural, guttate, pustular or erythrodermic. Psoriasis has a major genetic component, with heritability estimated to be 60-90%. High-impact and difficult-to-treat psoriasis sites include scalp, face, nails, genitalia, palms and soles. Recognition and management of comorbidities (such as psoriatic arthritis, psychological, cardiovascular and hepatic diseases) is an essential part of holistic care for individuals with psoriasis.
Psoriasis is a chronic, genetically influenced, remitting and relapsing scaly and inflammatory skin disorder that affects 1 to 3 percent of the world's population. The diagnosis is made on clinical grounds, although histologic examination of a skin-biopsy specimen may be helpful. Psoriasis is a disabling, though rarely life-threatening, disease with a social and economic impact that is underestimated by physicians and other health care providers. Recently, progress has been made in understanding the pathogenesis of psoriasis, and therapeutic advances are improving the care of even severely affected patients. There are several types of psoriasis, including pustular, guttate, and arthritic variants.
Microscopically, psoriasis is characterized by markedly increased proliferation and incomplete differentiation of the epidermis, a marked increase in cutaneous blood flow, and leukocytic infiltration of the papillary dermis and the epidermis. Evidence indicating that psoriasis is immunologically-mediated includes therapeutic response to immunosuppressant medications, transfer of the disease via bone marrow transplantation in humans and by purified T-cells in mice bearing human prepsoriatic skin, and the presence of clonal T-cell receptor (TCR) rearrangements in psoriatic skin.
Acalypha indica Linn. is a weed, used traditionally for different skin diseases such as eczema and dermatitis in various parts of India. There are no previous in vivo studies reported on the antipsoriatic potential of this medicinal
COMPONENTS OF THE FORMULATION
COLD PRESSED COCONUT OIL:
• Coconut oil helps to improve skin symptoms in people with chronic (long-term) skin conditions like psoriasis. As that coconut oil has anti-inflammatory properties that suppress inflammatory markers, which could help protect the skin from the inflammation caused by psoriasis.
COLD PRESSED OLIVE OIL:
• High in omega-3 fatty acids and vitamin E, olive oil appears to ease psoriasis symptoms in multiple ways. Olive oil is a great moisturizer that does double duty as an anti-inflammatory to calm irritated skin.
ALMOND OIL:
• Almond oil is equipped to fight both inflammation and vitamin deficiency. Its anti-inflammatory and antioxidant properties may help reduce inflammation, boost antioxidant levels and address scarring.
APRICOT OIL:
• Apricot kernel oil possesses anti-inflammatory properties, making it highly beneficial for those with sensitive or irritated skin. It can help alleviate common conditions like psoriasis and eczema by reducing redness, itching, and irritation.
VETPALAI LEAF:
• Analgesic, anti-inflammatory, and antipyretic activities and it is a highly cited medication for the treatment of psoriasis.
KUPPAIMENI LEAVES:
• Kuppaimeni has both amazing antibacterial and anti-fungal properties making it one of the best ingredients to use for skin care. It helps in Skin Polishing, Replenishing & Rejuvenation, Skin Brightening, Softening & Smoothening.
CHICKWEEDS LEAVES:
• Contains relatively high amounts of vitamins, which may partly explain its use as a topical treatment for skin irritations and itching.
MARJORAM:
• Marjoram acts as a natural antiseptic that helps prevent infections and lighten dark skin areas.
EMULSIFIYING WAX:
• Emulsifying wax assists in improving the consistency and texture of final products without leaving a greasy film on the outer skin after application. It acts as a mild stabilizer and thickener.
CETYL ALCOHOL:
• Some types of alcohol can be beneficial, like those that come from plants and are sources of healthy fatty acids. They include cetyl alcohol and stearyl alcohol. These types of alcohol are great moisturizers and help the skin feel softer.
DETAILED COMPONENTS OF THE FORMULATION:
The moisturising composition is formulated using 4 phases , phase A, B, C and D , where the components are discussed in detail in the below table
phase Function Benefits Weight(g) %
Phase A
Water Diluent hydrated and refreshed and helps maintain skin's elasticity 80.70 80.7
silica Texturizer skin regeneration - silica is strongly linked with healthy youthful skin 2.50 2.5
Propanediol Humectant move forward obstruction work, give antioxidant assurance, and improve the viability of other anti-aging fixings 5.00 5
Xanthan gum Thickener only naturally-derived thickeners 0.5 0.5
Phase B
Stearic Acid Emulsifier effective in moisturizing and hydrating the skin 2.00 2
Squalane Emollient offer assistance with skin break out and skin inflammation 2.00 2
Cetyl Alcohol Emollient to treat or avoid dry, unpleasant, flaky, bothersome skin and minor skin aggravations 1.50 1.5
Salicylic Acid Exfoliator prevents acne along with other skin conditions, like warts, psoriasis, calluses and corns 1.00 1
Phase C
Banana leaf extract Anti-microbial
Agent Rich in antioxidant and allanation 2.00 2
Momordica charantia leaf extract Botanical traditional medicinal plants for wound healing is based on their antiseptic, astringent, anti-inflammatory, and antimicrobial properties 0.5 0.5
Stellaria media leaf extract Botanical offers antioxidant and soothing properties 0.5 0.5
Marjoram extract Botanical refines the skin, thereby making the skin radiant 0.5 0.5
wrightia tinctoria extract Botanical used to treat psoriasis, eczema, scabies 0.5 0.5
Acalypha Indica extract Botanical used traditionally for different skin diseases such as eczema and dermatitis 0.5 O.5
Triethanolamine pH Adjuster balance the pH of formulations 0.3 0.3

Other ingredients include 1. cold pressed coconut oil, 2. cold pressed olive oil, 3. almond oil and 4. apricot kernel oil
PREPARATION PROCESS
The preparation process of the moisturising formulation, all the four phases of the formulation are prepared as below
Phase A:
Mix Silica with the water beneath tall sheer. Pre-mix the propanediol and
at that point include to the over, mix beneath tall sheer. Warm to 75C.
Phase B:
Combine fixings and warm to 75C.
Add phase B to phase A under shear mixing. Homogenize for a short time.
Phase C: includes the herbal component of the formulation comprising:
1. Vetpalai : [wrightia tinctoria] getrid of skin disease.
2. Marikozhundhu : the [marjoram] natural antiseptic , prevents infection , and treats acne .
3. Kuppaimeni : [acalypha indica] it helps in skin polishing ,replenishing and rejuvenation .
4. Chickweeds [stellaria media] : reduces inflamation and skin ailments
5. Bittergourd leaves [ mordica charintia] : powerhouse of nutrients like vitamin a ,c , calcium and antioxidants .
We follow a sundry infusion method where we dry our valuable herbs in sunlight for 3 days, there after infuse the herbs in olive oil and again sundry for 4 weeks, then add one by one, blending well.
The pH of the cream is 4.0.
The process of preparation is illustrated in figure 1
EXAMPLE/ PATIENT TESTING:
The present composition has been tried on subjects / patients affected by Psoriasis under doctors' supervision and have found the below results
1. Patient 2
Who is suffering from early stage of the Psoriasis
Uses the formulation once a day
It relieves from scaly, dry and itchy skin
When the patient uses moisturizing formulation two times a day (morning and night)
The patient condition after using moisturizing formulation (for 22 days) provides the below relief
• It removes scales and stops skin cells from growing so quickly.
• It slows down the production of skin cells and suppresses inflammation.
2. PATIENT 2 - Moderate stage
Before using moisturizing formulation, the patient had symptoms of
• Skin rashes, changes in fingernails and toenails.
• Red scaly plaques with well-defined edges.
The patient uses moisturizing formulation once a day (night) for 14 days the results showed are as below
• Gradual reduction in scale accumulation.
The said composition and formulation can be used in the form of body oil, shampoo, soap, gel etc.
, Claims:1. A moisturizing formulation comprising:
Phase A, including water, silica , propanediol , xanthan gum in the ratio of 80.7, 2.50, 5 and 0.5% w/v respectively;
Phase B, including stearic acid, squalane, cetyl alcohol, salicylic acid in the ratio of 2,2,1.5,1 % w/v respectively and
Phase C, including banana leaf extract, Momordica charantia leaf extract, Stellaria media leaf extract, marjoram extract, wrightia tinctoria extract, acalypha indica extract along with Ph adjuster in the ratio of 2,0.5,0.5,0.5,0.5,0.5,0.3 respectively.
2. A moisturizing formulation as claimed in claim 1 wherein the pH adjuster is Triethanolamine.
3. A moisturizing formulation as claimed in claim 1 can be in the form of shampoo, body oil, soap etc.
4. The method of preparation of moisturizing formulation comprises steps of :
e) Preparation of Phase A, by mixing the required amounts of silica with water and add the premix of proanediol at a temperature of 75 deg Centrigrade,
f) Preparation of phase B, by mixing the required amounts of stearic acid, squalane , cetyl alcohol and salicylic acid at the temperature 75 deg Centrigrade,
g) Preparation of Phase C, by mixing banana leaf extract, Momordica charantia leaf extract, Stellaria media leaf extract, marjoram extract, wrightia tinctoria extract, acalypha indica extract and adjusting the pH to 4.0 using pH adjuster triethanolamine.

5. The method of preparation of moisturizing formulation as claimed in claim 4 wherein the extracts of phase C are extracted in two steps:
iii. sundry all the herbs under sunlight for 3 days and
iv. infuse the herbs in olive oil and sundry for at least 3 weeks

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