METHOD FOR SYNTHESIZING CHROMONE-BASED SCHIFF BASES

Abstract

ABSTRACT A method (100) for synthesizing chromone-based Schiff bases comprising: preparing a chromone derivative by reacting a suitable precursor with a reagent; mixing the chromone derivative with a primary amine in the presence of a catalyst under optimized reaction conditions; isolating and purifying the resulting Schiff base; and characterizing the synthesized Schiff base to confirm its structure and purity. <>

Specification

Description:FIELD OF THE DISCLOSURE
[0001] This invention generally relates to a field of organic chemistry, and in particular, to a method for synthesizing chromone-based Schiff bases. The invention aims to provide a novel and efficient synthesis method for these compounds, which are known for their potential biological activities and applications in medicinal chemistry.
BACKGROUND

[0002] The subject matter discussed in the background section should not be assumed to be prior art merely as a result of its mention in the background section. Similarly, a problem mentioned in the background section or associated with the subject matter of the background section should not be assumed to have been previously recognized in the prior art. The subject matter in the background section merely represents different approaches, which in and of themselves may also correspond to implementations of the claimed technology.
[0003] Chromone-based compounds are known for their diverse range of biological activities, including anticance , Claims:1. A method (100) for synthesizing chromone-based Schiff bases comprising:
preparing a chromone derivative by reacting a suitable precursor with a reagent;
mixing the chromone derivative with a primary amine in the presence of a catalyst under optimized reaction conditions;
isolating and purifying the resulting Schiff base; and
characterizing the synthesized Schiff base to confirm its structure and purity.

2. The method (100) as claimed in claim 1, wherein the chromone derivative is prepared by reacting 2-hydroxyacetophenone with malonic acid.

3. The method (100) as claimed in claim 1, wherein the primary amine includes aniline or its derivatives.

4. The method (100) as claimed in claim 1, wherein the catalyst is selected from the group consisting of acetic acid and sodium hydroxide.

5. The method (100) as claimed in claim 1, wherein the characterization of the synthesized Schiff base is performed using techniques including nuclear magnetic resonance (NMR) spectroscopy, infrared (IR) spectroscopy, and mas

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