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HERBOXIDIENE ANTIBODY-DRUG CONJUGATES AND METHODS OF USE
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HERBOXIDIENE ANTIBODY-DRUG CONJUGATES AND METHODS OF USE
DIVISIONAL PCT NATIONAL PHASE APPLICATION
Published
Filed on 25 November 2024
Abstract
HERBOXIDIENE ANTIBODY-DRUG CONJUGATES AND METHODS OF USE Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a herboxidiene splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibodydrug conjugates provided herein. The herboxidiene itself is also claimed. Further claims are directed to its use, and to the use of a neoantigen, generated by the herboxidiene or its ADC, or a vaccine against this neoantigen.
Patent Information
| Application ID | 202448091830 |
| Invention Field | CHEMICAL |
| Date of Application | 25/11/2024 |
| Publication Number | 48/2024 |
Inventors
| Name | Address | Country | Nationality |
|---|---|---|---|
| FISHKIN, Nathan | 21 Chisholm Road, Weymouth, Massachusetts 02190, USA | U.S.A. | U.S.A. |
| SAMARAKOON, Thiwanka | 1531 High Street, Westwood, Massachusetts 02090, USA | Sri Lanka | Sri Lanka |
| PALACINO, James | 21 Beechwood Road, Wellesley, Massachusetts 02482, USA | U.S.A. | U.S.A. |
| ARAI, Kenzo | c/o Eisai Co., Ltd. Tsukuba Research Laboratories, 5-1-3 Tokodai Tsukuba-shi, Ibaraki 300-2635, Japan | Japan | Japan |
| KOTAKE, Yoshihiko | c/o Eisai Co., Ltd. Tsukuba Research Laboratories, 5-1-3 Tokodai Tsukuba-shi, Ibaraki 300-2635, Japan | Japan | Japan |
| OKUBO, Shinya | c/o Eisai Co., Ltd. Tsukuba Research Laboratories, 5-1-3 Tokodai Tsukuba-shi, Ibaraki 300-2635, Japan | Japan | Japan |
| MURAI, Norio | c/o Eisai Co., Ltd. Tsukuba Research Laboratories, 5-1-3 Tokodai Tsukuba-shi, Ibaraki 300-2635, Japan | Japan | Japan |
| MIYANO, Masayuki | c/o Eisai Co., Ltd. Tsukuba Research Laboratories, 5-1-3 Tokodai, Tsukuba-shi, Ibaraki 300-2635, Japan | Japan | Japan |
Applicants
| Name | Address | Country | Nationality |
|---|---|---|---|
| Eisai R&D Management Co., Ltd. | 6-10, Koishikawa 4-chome, Bunkyo-ku, Tokyo 112-8088, Japan | Japan | Japan |
Specification
Description:Please refer uploaded file , Claims:Please refer uploaded file
Documents
| Name | Date |
|---|---|
| 202448091830-FORM-26 [28-11-2024(online)].pdf | 28/11/2024 |
| 202448091830-COMPLETE SPECIFICATION [25-11-2024(online)].pdf | 25/11/2024 |
| 202448091830-DECLARATION OF INVENTORSHIP (FORM 5) [25-11-2024(online)].pdf | 25/11/2024 |
| 202448091830-DRAWINGS [25-11-2024(online)].pdf | 25/11/2024 |
| 202448091830-FORM 1 [25-11-2024(online)].pdf | 25/11/2024 |
| 202448091830-FORM 18 [25-11-2024(online)].pdf | 25/11/2024 |
| 202448091830-POWER OF AUTHORITY [25-11-2024(online)].pdf | 25/11/2024 |
| 202448091830-PRIORITY DOCUMENTS [25-11-2024(online)].pdf | 25/11/2024 |
| 202448091830-PROOF OF RIGHT [25-11-2024(online)].pdf | 25/11/2024 |
| 202448091830-REQUEST FOR EXAMINATION (FORM-18) [25-11-2024(online)].pdf | 25/11/2024 |
| 202448091830-Sequence Listing in PDF [25-11-2024(online)].pdf | 25/11/2024 |
| 202448091830-Sequence Listing in txt [25-11-2024(online)].txt | 25/11/2024 |
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