DRY FLOWABLE COMPOSITION OF NITENPYRAM, AND PYMETROZINE

Abstract

ABSTRACT DRY FLOWABLE COMPOSITION OF NITENPYRAM, AND PYMETROZINE The present invention relates to a dry flowable agricultural composition of nitenpyram, and pymetrozine. More specifically, synergistic dry flowable (DF) insecticidal composition of nitenpyram, pymetrozine along with suitable agrochemical additives, and its preparation thereof.

Specification

Description:FORM 2
THE PATENTS ACT 1970
(SECTION 39 OF 1970)
&
THE PATENT RULES, 2003
COMPLETE SPECIFICATION
(Section 10 and Rule 13)
1. Title of the invention:
DRY FLOWABLE COMPOSITION OF NITENPYRAM, AND PYMETROZINE

2. Applicant(s):
NAME NATIONALITY ADDRESS
COROMANDEL INTERNATIONAL LIMITED Indian Coromandel House, 1-2-10,
Sardar Patel Road, Secunderabad,
Telangana-500003, India.
3. Preamble to the description

The following specification particularly describes the invention and the manner in which it is to be performed.

 
FIELD OF THE INVENTION

The present invention relates to a dry flowable agricultural composition of nitenpyram, and pymetrozine. More specifically, a synergistic dry flowable (DF) insecticidal composition of nitenpyram, pymetrozine along with suitable agrochemical additives, and its preparation thereof.

BACKGROUND OF THE INVENTION

Insecticides are agrochemicals in the pesticide family which are used to control insects by killing them or preventing the establishment or proliferation of those considered harmful. They play a key role in agriculture and public health by improving the yield and productivity of crops by controlling pests and by reducing the rate of vector-borne diseases by killing or affecting growth and development of vectors such as mosquitoes, houseflies, tsetse flies, sand flies, cockroaches, etc.

Insecticides work differently based on their mode of actions; some disrupt the nervous system, whereas others damage the exoskeletons, others repel or control insects. Insecticides application helps in managing and mitigating insects; thereby guaranteeing crop protection and preventing yield loss.

A process for the preparation of insecticidal compositions which allows for reduced effective dosage rates, increased environmental safety and lower incidence of insect resistance are highly desirable. Although the rotational application of insect control agents having different modes of action may be adopted for good pest management practice, this approach does not necessarily give satisfactory insect control. Further, even though combinations of insect control agents have been studied, a high synergistic action has not always been found. Obtaining an insecticidal composition which demonstrates no cross-resistance to existing insecticidal agents, no toxicity problems and little negative impact on the environment is extremely difficult.

Insecticides are used widely and very frequently in commercial agriculture and have enabled an enormous increase in crop yields and product quality which ultimately increased the ease to farmers in terms of economic advantage as well as ease of farming activities.

CN101297649B discloses a pesticide composite containing pymetrozine, comprising a first active ingredient: pymetrozine and a second active ingredient: effective cyhalothrin, nitenpyram or chlorpyrifos.

CN101601391A discloses water dispersible granules composition comprising of nitenpyram and pymetrozine.

CN101911941A discloses pesticide composition comprises nitenpyram, and pymetrozine and the balance of auxiliary agents and carriers, and the pesticide composition can be prepared into water dispersible granules.

It may be noted that none of the above-mentioned prior references discloses dry flowable (DF) insecticide composition of Nitenpyram and Pymetrozine combination.

The present inventors have developed a dry flowable (DF) agrochemical insecticidal composition of Nitenpyram, and Pymetrozine.

Dry flowable formulations, also known as "DF" or "dry flowable powders," are commonly used in the agricultural and pharmaceutical industries. They consist of finely ground solid ingredients that are easy to handle and reconstitute.

The present invention desired to provide improved insecticidal dry flowable compositions and convenient methods that are efficient against sucking pests of various crops and plants including rice, serves as good tool for resistance management, shows technical advancement over existing art and is of economic significance.

Dry flowables (DF) formulations allow greater flexibility in designing formulations with multiple active ingredients. The dry formulation can be tailored to include combinations of fungicides, or insecticides without risking chemical incompatibilities that might occur in liquid blends.

Dry flowables are often less susceptible to degradation due to environmental factors like light, heat, or oxygen, which can affect liquid formulations. The solid nature of the dry flowable ensures a longer shelf life and stability of the active ingredient. With dry flowables, users can more easily control the concentration and dosage by adjusting the amount of the product mixed with water, and easily disintegrate and disperse.


OBJECT OF THE INVENTION

One object of the present invention is to provide a dry flowable (DF) insecticidal composition comprising of nitenpyram, and pymetrozine along with suitable agrochemical additives.
Another object of the present invention is to provide a dry flowable insecticidal composition useful for synergistic insect control with enhanced crop protection and delayed dominance of the resistant strains of pests.
Another object of the present invention is to provide a dry flowable insecticidal composition that can improve biological performance in a single application and minimize occupational exposure and hazards.
Yet another object of the present invention is to provide dry flowable insecticidal composition that is effective against a wide variety of chewing, boring and sucking insects.




SUMMARY OF THE INVENTION

The present invention provides a dry flowable (DF) insecticidal composition comprising of nitenpyram, and pymetrozine along with suitable agrochemical additives. This composition demonstrates enhanced insecticidal activity, effectively controlling a broad spectrum of insect pests while also offering reduced toxicity to non-target organisms.

In an aspect of the present invention, a dry flowable (DF) insecticidal composition comprises suitable agrochemical additives selected from a wetting agent, a dispersing agent, an adjuvant, a defoamer, a disintegrating agent, a binder, and a filler.

In an aspect of the present invention, a dry flowable (DF) insecticidal composition comprising of:
a) an insecticide nitenpyram is present in an amount of 20.0% (w/w),
b) an insecticide pymetrozine is present in an amount of 60.0% (w/w),
c) a wetting agent is present in an amount from 1.0% (w/w) to 5.0% (w/w),
d) a dispersing agent is present in an amount from 1.0% (w/w) to 10.0% (w/w),
e) a defoamer is present in an amount from 0.1% (w/w) to 2.0% (w/w),
f) a filler is present in Q.S.

In another aspect of the present invention, a dry flowable (DF) insecticidal composition comprising of:
a) nitenpyram is present in an amount of 20.0 % (w/w),
b) pymetrozine is present in an amount of 60.0 % (w/w),
c) linear alcohol derivative is present in an amount of 2.0 % (w/w),
d) sodium salt of methyl naphthalene sulphonate condensate is present in an amount of 4.0% (w/w),
e) lignosulfonic acid, sodium salt, sulfomethylated is present in an amount of 2.0 % (w/w),
f) polydimethyl siloxane is present in an amount of 1.0 % (w/w),
g) starch is present in Q.S.
In another aspect of the present invention, a dry flowable (DF) insecticidal composition comprising of:
a) an insecticide nitenpyram is present in an amount of 20.0% (w/w),
b) an insecticide pymetrozine is present in an amount of 60.0% (w/w),
c) a wetting agent is present in an amount from 1.0% (w/w) to 5.0% (w/w),
d) a dispersing agent is present in an amount from 1.0% (w/w) to 10.0% (w/w),
e) a defoamer is present in an amount from 0.1% (w/w) to 2.0% (w/w),
f) an adjuvant is present in an amount from 1.0% (w/w) to 2.0% (w/w),
g) a disintegrating agent is present in an amount from 1.0% (w/w) to 10.0% (w/w),
h) a binder is present in an amount from 0.1% (w/w) to 2.0% (w/w), and
i) a filler is present in Q.S.

In another aspect of the present invention, the wetting agent is selected from linear alcohol derivative, sodium isopropyl naphthalene sulfonate, and naphthalene sulfonic acid and phenol sulphonic acid sodium salt.

In another aspect of the present invention, the dispersing agent is selected from sodium salt of naphthalene sulphonates formaldehyde condensate, Lignosulfonic acid, sodium salt, sulfomethylated, modified polyacrylate, acrylate copolymer, naphthalene sulfonic acid condensate and combination thereof.

In another aspect of the present invention, the defoamer is selected from polydimethylsiloxane, and silicone emulsion.

In another aspect of the present invention, the adjuvant is organo modified trisiloxane.

The organo modified trisiloxane also acts as rain fastness (tolerates rain after one hour of application) agents, which allows a larger amount of active ingredients to penetrate plant cuticle even under adverse conditions, thus saving spray volumes.


In another aspect of the present invention, the disintegrating agent is selected from sodium sulphate, urea formaldehyde resin, and combination thereof.

In another aspect of the present invention, the binder is polyvinyl pyrrolidone.

In another aspect of the present invention, the filler is selected from starch, and china clay.

In yet another aspect of the present invention is to provide a dry flowable (DF) insecticidal composition useful for enhanced insect control with enhanced crop protection and delayed dominance of the resistant strains of pests.

In yet another aspect of the present invention is to provide a dry flowable (DF) insecticidal composition that can improve biological performance in a single application and minimize occupational exposure and hazards.

In yet another aspect of the present invention is to provide a process for the preparation of a dry flowable (DF) insecticidal composition comprising of nitenpyram, and pymetrozine.

DESCRIPTION OF THE INVENTION

The following detailed description is presented to enable any person skilled in the art to make and use the invention. For purposes of explanation, specific nomenclature is set forth to provide a thorough understanding of the present application. However, it will be apparent to one skilled in the art that these specific details are not required to practice the invention. Descriptions of specific applications are provided only as representative examples. The present application is not intended to be limited to the embodiments shown but is to be accorded the widest possible scope consistent with the principles and features disclosed herein.

It is to be noted that, as used in the specification, the singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise. Thus, for example, reference to a composition containing "a compound" includes a mixture of two or more compounds. It should also be noted that the term "or" is generally employed in its sense including "and/or" unless the content clearly dictates otherwise.

Similarly, the words "comprise", "comprises", and "comprising" are to be interpreted inclusively rather than exclusively. Likewise, the terms "include", "including" and "or" should all be construed to be inclusive, unless such a construction is clearly prohibited from the context. However, the embodiments provided by the present disclosure may lack any element that is not specifically disclosed herein. Thus, a disclosure of an embodiment defined using the term "comprising" is also a disclosure of embodiments "consisting essentially of" and "consisting of" the disclosed components. Where used herein, the term "example", particularly when followed by a listing of terms, is merely exemplary and illustrative, and should not be deemed to be exclusive or comprehensive. Any embodiment disclosed herein can be combined with any other embodiment disclosed herein unless explicitly indicated otherwise.

The expression of various quantities in terms of "% w/w" or "%" means the percentage by weight, relative to the weight of the total solution or composition unless otherwise specified.

As used herein, the terms "insecticide" may be understood to include pesticides specifically used to destroy one or more species of insects.

As used herein, the term "synergistic composition" may be understood to include effective combination of more than one agrochemical that allows the application of the said agrochemical in a much lower dosage, which results in a less dosage treatment for the crops.


As used herein, the term "agrochemical additives" may be understood to include a range of surfactants, dispersing agents, organic or inorganic pigments, solvents, de-solvents, defoamers, emulsifiers, crystallization inhibitors, viscosity modifiers, suspending agents, dyes, antioxidants, foaming agents, mixing aids, neutralizers or pH adjusting substances and buffers, wetting agents, absorption enhancers, micronutrients, plasticizers, lubricants, thickeners, anti-freezing agents, and sterilization agents among others.

The present invention aims to develop a dry flowable (DF) insecticidal composition of nitenpyram, and pymetrozine along with suitable agrochemical additives.

Nitenpyram is a synthetic, nicotine-related insecticide, and influences the nicotinic acetylcholine receptors. This compound is an insect neurotoxin belonging to the class of neonicotinoids which works by blocking neural signaling of the central nervous system. It does so by binding irreversibly to the nicotinic acetylcholine receptor (nACHr) thereby stopping the flow of ions in the postsynaptic membrane of neurons leading to paralysis and death.

Nitenpyram is chemically known as (E)-N1-[(6-Chloropyridin-3-yl) methyl]-N1-ethyl-N′1-methyl-2-nitroethene-1,1-diamine, and has following structure:


Pymetrozine is a pyridine azomethine insecticide and is selective against Homopteran, causing them to stop feeding. It provides control of juvenile and adult stages of aphids and whiteflies in vegetables, potatoes, ornamental, cotton, deciduous fruit, citrus, tobacco and hops and planthoppers in rice.


Pymetrozine is chemically known as (E)-4,5-dihydro-6-methyl-4-(3-pyridyl methylene amino)-1,2,4-triazin3(2H)-one, has following structure.



One embodiment of the present invention is to provide a dry flowable (DF) insecticidal composition of nitenpyram, and pymetrozine along with suitable agrochemical additives.

In an embodiment of the present invention, a dry flowable (DF) insecticidal composition comprises suitable agrochemical additives selected from a wetting agent, a dispersing agent, an adjuvant, a defoamer, a disintegrating agent, a binder, and a filler.

In an embodiment of the present invention, a dry flowable (DF) insecticidal composition comprising of:
a) an insecticide nitenpyram is present in an amount of 20.0% (w/w),
b) an insecticide pymetrozine is present in an amount of 60.0% (w/w),
c) a wetting agent is present in an amount from 1.0% (w/w) to 5.0% (w/w),
d) a dispersing agent is present in an amount from 1.0% (w/w) to 10.0% (w/w),
e) a defoamer is present in an amount from 0.1% (w/w) to 2.0% (w/w),
f) a filler is present in Q.S.

In another embodiment of the present invention, a dry flowable (DF) insecticidal composition comprising of:
a) nitenpyram is present in an amount of 20.0 % (w/w),
b) pymetrozine is present in an amount of 60.0 % (w/w),
c) linear alcohol derivative is present in an amount of 2.0 % (w/w),
d) sodium salt of methyl naphthalene sulphonate condensate is present in an amount of 4.0% (w/w),
e) lignosulfonic acid, sodium salt, sulfomethylated is present in an amount of 2.0 % (w/w),
f) polydimethyl siloxane is present in an amount of 1.0 % (w/w),
g) starch is present in Q.S.

In another embodiment of the present invention, a dry flowable (DF) insecticidal composition comprising of:
a) an insecticide nitenpyram is present in an amount of 20.0% (w/w),
b) an insecticide pymetrozine is present in an amount of 60.0% (w/w),
c) a wetting agent is present in an amount from 1.0% (w/w) to 5.0% (w/w),
d) a dispersing agent is present in an amount from 1.0% (w/w) to 10.0% (w/w),
e) a defoamer is present in an amount from 0.1% (w/w) to 2.0% (w/w),
f) an adjuvant is present in an amount from 1.0% (w/w) to 2.0% (w/w),
g) a disintegrating agent is present in an amount from 1.0% (w/w) to 10.0% (w/w),
h) a binder is present in an amount from 0.1% (w/w) to 2.0% (w/w), and
i) a filler is present in Q.S.

A wetting agent is a substance that when added to a liquid increases the spreading or penetration power of the liquid by reducing the interfacial tension between the liquid and the surface on which it is spreading.

Accordingly, the composition of the present invention contains a wetting agent selected from the group comprising of linear alcohol derivative, sodium isopropyl naphthalene sulfonate, and naphthalene sulfonic acid and phenol sulphonic acid sodium salt.

A dispersant or a dispersing agent is a substance which absorbs onto the surface of particles and helps to preserve the state of dispersion of the particles and prevents them from re-aggregating. Dispersants are added to agrochemical compositions to facilitate dispersion and suspension during manufacture, and to ensure the particles re-disperse into water in a spray tank.

Accordingly, the composition of the present invention contains a dispersing agent selected from the group comprising of sodium salt of naphthalene sulphonates formaldehyde condensate, Lignosulfonic acid, sodium salt, sulfomethylated, modified polyacrylate, acrylate copolymer, naphthalene sulfonic acid condensate and combination thereof.

Defoamer is a chemical reagent developed for defoaming, and foam suppression based on the principle of foaming. The defoamer suitable for the purpose of the present invention is polydimethylsiloxane, and silicone emulsion.

An adjuvant suitable for the purpose of the present invention is organo modified trisiloxane.

The organo modified trisiloxane also acts as rain fastness (tolerates rain after one hour of application) agents, which allows a larger amount of active ingredients to penetrate plant cuticle even under adverse conditions, thus saving spray volumes.

The disintegrating agent suitable for the purpose of the present invention is selected from sodium sulphate, urea formaldehyde resin, and combination thereof.

The binder suitable for the purpose of the present invention is polyvinyl pyrrolidone.

A filler refers to solid chemicals that are added to a pesticide formulation to aid in the delivery of the active ingredient. Accordingly, the composition of the present invention contains a filler selected from starch, and china clay, present in Q.S.

In yet another embodiment, of the present invention is to provide a method for preparing a dry flowable (DF) insecticidal composition of nitenpyram and pymetrozine.


The present invention is further illustrated by the following examples which are provided merely to be exemplary of the inventions and are not intended to limit the scope of the invention. Certain modifications and equivalents will be apparent to those skilled in the art and are intended to be included within the scope of the present invention.

Examples:
Example 1: Nitenpyram 20% + Pymetrozine 60% DF
S. No. Composition Function Charge in (%)
1. Nitenpyram (Technical) Active ingredient 20.0
2. Pymetrozine (Technical) Active ingredient 60.0
3. Linear alcohol derivative Wetting agent 2.0
4. Sodium salt of methyl naphthalene sulphonate condensate Dispersing agent 4.0
5. Lignosulfonic acid, sodium salt, sulfomethylated Dispersing agent 2.0
6. Polydimethyl siloxane Defoamer 1.0
7. Starch Filler Q.S.

Procedure of preparation of Nitenpyram 20 % + Pymetrozine 60 % DF
Step 1: Weighing all the raw materials according to the batch size as follows:
 Nitenpyram technical
 Pymetrozine technical
 Linear alcohol derivative
 Sodium salt of methyl naphthalene sulphonate condensate
 Lignosulfonic acid, sodium salt, sulfomethylated
 Polydimethyl siloxane
 Starch
Step 2: Pre-blend all the raw materials in a ribbon blender for 1 hour.
Step 3: Milling the above pre-mixed material through air jet mill with Inlet pressure 2-2.5 kg/cm2 and grinding pressure 6- 7kg/ cm2
Step 4: Collecting the material from air jet and post -blend for 1 hour in ribbon blender.
Step 5: Granulation Process:
 Prepare the dough using a small amount of water.
 Extruding the granules through Basket extruder.
Step 6: Collect the granules and dry them in a Fluid bed drier at 60°C for 30 min with air flow of 40-50 psi. (Check the moisture content of the granules it should be maintained 10.0% w/w).
Step 7: Submitting the sample to QC for Analysis.
Step 8: Packing the material in the designated HDPE bottles.

Example 2: Nitenpyram 20% + Pymetrozine 60% DF
S. No. Composition Function Charge in (%)
1. Nitenpyram (Technical) Active ingredient 20.0
2. Pymetrozine (Technical) Active ingredient 60.0
3. Linear alcohol derivative Wetting agent 2.0
4. Sodium salt of methyl naphthalene sulphonate condensate Dispersing agent 4.0
5. Ligno sulfonic acid, sodium salt, sulfomethylated Dispersing agent 2.0
6. Organo modified trisiloxane Adjuvant 1.0
7. Polydimethyl siloxane Defoamer 1.0
8. Starch Filler Q.S.

The manufacturing process is similar to example 1.

Example 3: Nitenpyram 20% + Pymetrozine 60% DF
S. No. Composition Function Charge in (%)
1. Nitenpyram (Technical) Active ingredient 20.0
2. Pymetrozine (Technical) Active ingredient 60.0
3. Sodium isopropyl naphthalene sulfonate Wetting agent 3.0
4. Modified polyacrylate, acrylate copolymer Dispersing agent 3.0
5. Sodium salt of Naphthalene sulphonates formaldehyde condensate Dispersing agent 2.0
6. Ammonium sulphate Disintegrating Agent 5.0
7. Polyvinyl pyrrolidone Binder 0.1
8. Organo modified trisiloxane Adjuvant 1.0
9. Silicone emulsion Defoamer 0.1
10. China clay Filler Q.S.

The manufacturing process is similar to example 1.

Example 4: Nitenpyram 20% + Pymetrozine 60% DF
S. No. Composition Function Charge in (%)
1. Nitenpyram (Technical) Active ingredient 20.0
2. Pymetrozine (Technical) Active ingredient 60.0
3. Naphthalene sulfonic acid condensate Dispersing agent 3.0
4. Naphthalene sulfonic acid and phenol sulphonic acid Sodium salt Wetting agent 2.0
5. Sodium sulphate Disintegrating Agent 5.0
6. Polyvinyl pyrrolidone Binder 1.0
7. Organo modified trisiloxane Adjuvant 1.0
8. Urea formaldehyde resin Disintegrating Agent 1.0
9. Silicone emulsion Defoamer 0.1
10. China clay Filler Q.S.

The manufacturing process is similar to example 1.





Efficacy study of Nitenpyram 20% + Pymetrozine 60% in a dry flowable (DF) form:

SYNERGY STUDIES:

A synergistic effect exists whenever the action of an active ingredient combination is greater than the sum of the actions of the individual components.

After calculating % disease control, the synergism was calculated by the below formula: The synergistic pesticidal action of the inventive mixtures is calculated by Colby's formula. Appropriate analysis of plant response to pesticide combination is critical in determining the type of activity observed. The most widely used model is the one Gowing* derived and Colby** modified. Gowing described a mathematical formula for calculating the predicting response values for pesticide mixtures. He suggested the expected (E) percent inhibition of growth induced by pesticide A plus pesticide B is as follows, *(Jerry Flint et al, 1988) ***

The synergistic action expected for a given combination of two active components can be calculated as follows:
AB
Expected (E) = A + B -
100

Where:
A - Percentage of pesticidal control observed by compound A.
B - Percentage of pesticidal control observed by compound B.

When the percentage of pesticidal control observed for the combination is greater than the expected percentage, there is a synergistic effect. (Ratio of O/E > 1, means synergism observed.)



Reference:
*Gowing, D. P. 1960. Comments on tests of herbicide mixtures. Weeds 8:379-391.
**Colby, S. R. 1967. Calculating synergistic and antagonistic responses of herbicide combinations. Weeds 15:20-22
*** Jerry Flint et al, 1988. Analyzing Herbicide Interactions: A Statistical Treatment of Colby's Method. Weed Technology 2: 304-309

Trial on Rice pests:

Rice (Oryza sativa) is the most important, and a staple food for more than half the world's population and has grown in over 100 countries. India is the world's second-largest producer of Rice, and the largest exporter of rice in the world

The regions cultivating this crop in India are distinguished as the western coastal strip, the eastern coastal strip, covering all the primary deltas, Assam plains and surrounding low hills, foothills and Terai region- along the Himalayas and states like West Bengal, Bihar, eastern Uttar Pradesh, eastern Madhya Pradesh, northern Andhra Pradesh and Odisha. India, being a land of the eternal growing season, and the deltas of the Ganges-Bramhaputra (in West Bengal), Kaveri River, Krishna River, Godavari River, Indravati River and Mahanadi River with a thick set-up of canal irrigation like Hirakud Dam and Indravati Dam, permits farmers to raise two, and in some pockets, even three crops a year. Irrigation has made even three crops a year possible.

Irrigation has made it feasible even for Punjab and Haryana, known for their baked climate, to grow rice. They even export their excess to other states.

Punjab and Haryana grow prized rice for export purposes. The hilly terraced fields from Kashmir to Assam are ideally suited for rice farming, with age-old hill irrigational conveniences. High yielding kinds, enhanced planting methods, promised irrigation water supply and mounting use of fertilizers have together led to beneficial and quick results. It is the rain fed area that cuts down average yields per hectare.
The field efficacy trials were conducted in Rice, on Rice pest complex. The Rice pest complex viz., Brwon plant hopper (BPH) (Nilaparvata lugens) (Stal), White backed planthopper (WBPH) (Sogatella furcifera) (Horvath) and green leaf hopper (GLH) (Nephotettix virescens) (Distant) cause severe damage and serious threat to Rice crop at panicle initiation stage and can also affect the crop stand and yield.

Trials were conducted to evaluate the efficacy of a dry flowable (DF) composition of Nitenpyram and Pymetrozine combination.

Trials were conducted with randomized block design with net plot size of 5m x 8m = 40 Sq mt. Rice crop was raised with all standard agronomic practices. Spraying was done with manual operated backpack sprayer with 500 liters of water spray volume per hectare at 45-60 days after planting. The observations were recorded by counting the nod of BPH, WBPH and GLH per hill, considered ten hills per plot. The observations were recorded before spraying, 10 DAA (Days after application).

Table 1: Efficacy of Brown plant hopper (BPH), White backed plant hopper (WBPH), Green leaf hopper (GLH) pests' control in Rice at 5 and 10 Days After Application (DAA):

Compositions
GAI/ha % Insect Control at 5 DAA % Insect Control at 10 DAA
BPH WBPH GLH BPH WBPH GLH
Nitenpyram 25% SP 175 82.3 84.2 50.2 76.4 77.3 38.4
Pymetrozine 50% WG 150 78.2 62.2 32.5 64.8 53.5 20.2
Nitenpyram 20% + Pymetrozine 60% DF 150 98.6 99.2 93.3 96.4 97.7 92.7
Dry Flowable (DF); SP- Soluble Powder; WG- Wettable Granules; DAA -Days after Application.

The solo as well as the combination of two active ingredients tested here against Rice BPH, WBPH and GLH. Table 1 shows excellent efficacy of Nitenpyram 20% + Pymetrozine 60% dry flowable (DF) composition against Rice BPH, WBPH and GLH complex.
Table2: Efficacy of Brown plant hopper (BPH), White backed plant hopper (WBPH), Green leaf hopper (GLH) pests' control in Rice at 10 Days After Application (DAA)

Compositions
GAI/ha % Insect Control at 10 DAA
BPH WBPH GLH
Exp Obs. Exp Obs. Exp Obs.
Nitenpyram 25% SP 175 76.4 77.3 38.4
Pymetrozine 50% WG 150 64.8 53.5 20.2
Nitenpyram 20% + Pymetrozine 60% DF 150 91.5 96.4 90.3 97.7 82.6 91.7
Ratio of O/E 1.05 1.08 1.11
*Exp- Expected & Obs.- Observed, and DAA Days after application.

The trial results in Table 2 show synergistic effect of Nitenpyram 20% + Pymetrozine 60% dry flowable (DF) composition against BPH, WBPH & GLH on Rice crops. The higher ratio of the observed and the expected efficacy clearly demonstrates the synergistic effect of the combination.

 
Claims:

1. A dry flowable (DF) insecticidal composition comprising of:
a) an insecticide nitenpyram is present in an amount of 20.0% (w/w),
b) an insecticide pymetrozine is present in an amount of 60.0% (w/w),
c) a wetting agent is present in an amount from 1.0% (w/w) to 5.0% (w/w),
d) a dispersing agent is present in an amount from 1.0% (w/w) to 10.0% (w/w),
e) a defoamer is present in an amount from 0.1% (w/w) to 2.0% (w/w),
f) a filler is present in Q.S.

2. The insecticidal composition as claimed in claim 1, wherein the wetting agent is selected from the group comprising of linear alcohol derivative, sodium isopropyl naphthalene sulfonate, and naphthalene sulfonic acid and phenol sulphonic acid sodium salt.

3. The insecticidal composition as claimed in claim 1, wherein the dispersing agent selected from the group comprising of sodium salt of naphthalene sulphonates formaldehyde condensate, Lignosulfonic acid, sodium salt, sulfomethylated, modified polyacrylate, acrylate copolymer, naphthalene sulfonic acid condensate and combination thereof.


4. The insecticidal composition as claimed in claim 1, wherein the defoamer is selected from polydimethylsiloxane, and silicone emulsion.

5. The insecticidal composition as claimed in claim 1, wherein the filler is starch.


6. The insecticidal composition as claimed in claim 1, wherein a dry flowable (DF) insecticidal composition comprising of:
a) nitenpyram is present in an amount of 20.0 % (w/w),
b) pymetrozine is present in an amount of 60.0 % (w/w),
c) linear alcohol derivative is present in an amount of 2.0 % (w/w),
d) sodium salt of methyl naphthalene sulphonate condensate is present in an amount of 4.0% (w/w),
e) lignosulfonic acid, sodium salt, sulfomethylated is present in an amount of 2.0 % (w/w),
f) polydimethyl siloxane is present in an amount of 1.0 % (w/w),
g) starch is present in Q.S.

Dated this Twenty-first (21st) day of November 2024



Sahadev Katam
General Manager, Legal-IPR
Coromandel International Limited
Registered Patent Agent No. IN/PA/5560
, Claims:Claims:

1. A dry flowable (DF) insecticidal composition comprising of:
a) an insecticide nitenpyram is present in an amount of 20.0% (w/w),
b) an insecticide pymetrozine is present in an amount of 60.0% (w/w),
c) a wetting agent is present in an amount from 1.0% (w/w) to 5.0% (w/w),
d) a dispersing agent is present in an amount from 1.0% (w/w) to 10.0% (w/w),
e) a defoamer is present in an amount from 0.1% (w/w) to 2.0% (w/w),
f) a filler is present in Q.S.

2. The insecticidal composition as claimed in claim 1, wherein the wetting agent is selected from the group comprising of linear alcohol derivative, sodium isopropyl naphthalene sulfonate, and naphthalene sulfonic acid and phenol sulphonic acid sodium salt.

3. The insecticidal composition as claimed in claim 1, wherein the dispersing agent selected from the group comprising of sodium salt of naphthalene sulphonates formaldehyde condensate, Lignosulfonic acid, sodium salt, sulfomethylated, modified polyacrylate, acrylate copolymer, naphthalene sulfonic acid condensate and combination thereof.


4. The insecticidal composition as claimed in claim 1, wherein the defoamer is selected from polydimethylsiloxane, and silicone emulsion.

5. The insecticidal composition as claimed in claim 1, wherein the filler is starch.


6. The insecticidal composition as claimed in claim 1, wherein a dry flowable (DF) insecticidal composition comprising of:
a) nitenpyram is present in an amount of 20.0 % (w/w),
b) pymetrozine is present in an amount of 60.0 % (w/w),
c) linear alcohol derivative is present in an amount of 2.0 % (w/w),
d) sodium salt of methyl naphthalene sulphonate condensate is present in an amount of 4.0% (w/w),
e) lignosulfonic acid, sodium salt, sulfomethylated is present in an amount of 2.0 % (w/w),
f) polydimethyl siloxane is present in an amount of 1.0 % (w/w),
g) starch is present in Q.S.

Documents