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CONJUGATED OLIGONUCLEOTIDES AND USES THEREOF
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CONJUGATED OLIGONUCLEOTIDES AND USES THEREOF
PCT NATIONAL PHASE APPLICATION
Published
Filed on 26 April 2024
Abstract
Provided herein are oligomeric compounds comprising a bicycle ligand and a modified oligonucleotide. This compound may comprise a bicycle ligand as the cell-targeting moiety, and may also comprise a conjugate linker to connect the bicycle ligand and modified oligonucleotide. This compound may be used in conjunction with a phamaceutically acceptable salt.
Patent Information
| Application ID | 202447033262 |
| Invention Field | CHEMICAL |
| Date of Application | 26/04/2024 |
| Publication Number | 18/2024 |
Inventors
| Name | Address | Country | Nationality |
|---|---|---|---|
| SETH, Punit, P. | 6773 Mallee St. Carlsbad, CA 92011 | U.S.A. | U.S.A. |
| OESTERGAARD, Michael | 2855 Gazelle Court Carlsbad, CA 92010 | U.S.A. | U.S.A. |
| CARRER, Michele | 2855 Gazelle Court Carlsbad, CA 92010 | U.S.A. | U.S.A. |
| TANOWITZ, Michael | 2855 Gazelle Court Carlsbad, CA 92010 | U.S.A. | U.S.A. |
| RIGBY, Michael | Building 900 Babraham Research Campus Cambridge CB22 3AT | U.K. | U.K. |
| SKYNNER, Michael | Building 900 Babraham Research Campus Cambridge CB22 3AT | U.K. | U.K. |
| STANWAY, Steven | Building 900 Babraham Research Campus Cambridge CB22 3AT | U.K. | U.K. |
| URBONAS, Liudvikas | Building 900 Babraham Research Campus Cambridge CB22 3AT | U.K. | U.K. |
| VAN RIETSCHOTEN, Katerine | Building 900 Babraham Research Campus Cambridge CB22 3AT | U.K. | U.K. |
Applicants
| Name | Address | Country | Nationality |
|---|---|---|---|
| IONIS PHARMACEUTICALS, INC. | 2855 Gazelle Court Carlsbad, CA 92010 | U.S.A. | U.S.A. |
| BICYCLE TX LIMITED | Building 900 Babraham Research Campus Cambridge GB CB22 3AT | U.K. | U.K. |
Documents
| Name | Date |
|---|---|
| 202447033262-COMPLETE SPECIFICATION [26-04-2024(online)].pdf | 26/04/2024 |
| 202447033262-DECLARATION OF INVENTORSHIP (FORM 5) [26-04-2024(online)].pdf | 26/04/2024 |
| 202447033262-FORM 1 [26-04-2024(online)].pdf | 26/04/2024 |
| 202447033262-FORM 18 [26-04-2024(online)].pdf | 26/04/2024 |
| 202447033262-PRIORITY DOCUMENTS [26-04-2024(online)].pdf | 26/04/2024 |
| 202447033262-REQUEST FOR EXAMINATION (FORM-18) [26-04-2024(online)].pdf | 26/04/2024 |
| 202447033262-Sequence Listing in PDF [26-04-2024(online)].pdf | 26/04/2024 |
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