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COMPOSITIONS AND METHODS FOR TREATING LIVER DISEASES WITH SIRNAS TARGETING GPAM
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COMPOSITIONS AND METHODS FOR TREATING LIVER DISEASES WITH SIRNAS TARGETING GPAM
PCT NATIONAL PHASE APPLICATION
Published
Filed on 6 November 2024
Abstract
Disclosed herein are compositions comprising siRNAs capable of downregulating Glycerol-3-Phosphate Acyltransferase, Mitochondrial (GPAM) gene expression or a variant thereof. Also disclosed herein are methods of using such compositions in the treatment of a liver disease or injury, such as fatty liver disease (FLD), non-alcoholic fatty liver disease (NAFLD) or non-alcoholic steatohepatitis (NASH).
Patent Information
| Application ID | 202447085002 |
| Invention Field | CHEMICAL |
| Date of Application | 06/11/2024 |
| Publication Number | 46/2024 |
Inventors
| Name | Address | Country | Nationality |
|---|---|---|---|
| ZHU, Hao | 5323 Harry Hines Boulevard Dallas, Texas 75390 | U.S.A. | U.S.A. |
| WANG, Zixi | 5323 Harry Hines Boulevard Dallas, Texas 75390 | U.S.A. | U.S.A. |
| LI, Lin | 5323 Harry Hines Boulevard Dallas, Texas 75390 | U.S.A. | U.S.A. |
Applicants
| Name | Address | Country | Nationality |
|---|---|---|---|
| THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 210 West 7th Street Austin, Texas 78701 | U.S.A. | U.S.A. |
Documents
| Name | Date |
|---|---|
| 202447085002-FORM-26 [07-11-2024(online)].pdf | 07/11/2024 |
| 202447085002-COMPLETE SPECIFICATION [06-11-2024(online)].pdf | 06/11/2024 |
| 202447085002-DECLARATION OF INVENTORSHIP (FORM 5) [06-11-2024(online)].pdf | 06/11/2024 |
| 202447085002-DRAWINGS [06-11-2024(online)].pdf | 06/11/2024 |
| 202447085002-EVIDENCE FOR REGISTRATION UNDER SSI(FORM-28) [06-11-2024(online)].pdf | 06/11/2024 |
| 202447085002-FORM 1 [06-11-2024(online)].pdf | 06/11/2024 |
| 202447085002-FORM 18 [06-11-2024(online)].pdf | 06/11/2024 |
| 202447085002-FORM FOR SMALL ENTITY(FORM-28) [06-11-2024(online)].pdf | 06/11/2024 |
| 202447085002-NOTIFICATION OF INT. APPLN. NO. & FILING DATE (PCT-RO-105-PCT Pamphlet) [06-11-2024(online)].pdf | 06/11/2024 |
| 202447085002-PRIORITY DOCUMENTS [06-11-2024(online)].pdf | 06/11/2024 |
| 202447085002-PROOF OF RIGHT [06-11-2024(online)].pdf | 06/11/2024 |
| 202447085002-REQUEST FOR EXAMINATION (FORM-18) [06-11-2024(online)].pdf | 06/11/2024 |
| 202447085002-Sequence Listing in PDF [06-11-2024(online)].pdf | 06/11/2024 |
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