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ANTIBODIES TO CD3 AND BCMA, AND BISPECIFIC BINDING PROTEINS MADE THEREFROM
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ANTIBODIES TO CD3 AND BCMA, AND BISPECIFIC BINDING PROTEINS MADE THEREFROM
DIVISIONAL PCT NATIONAL PHASE APPLICATION
Published
Filed on 5 November 2024
Abstract
ABSTRACT “ANTIBODIES TO CD3 AND BCMA, AND BISPECIFIC BINDING PROTEINS MADE THEREFROM” High-affinity antibodies recognizing CD3 and B Cell Maturation Factor protein (BCMA) are Provided. Binding sites from humanized anti-CD3 and anti-BCMA antibodies are incorporated into a Fabs-in-Tandem Immunoglobulin format without significant loss of binding affinity, and the resultant bispecific, multivalent binding proteins are able to bind to both CD3 and BCMA simultaneously. Such antibodies, antigen-binding portions thereof, and bispecific FIT-Ig binding proteins are useful for treating cancer.
Patent Information
| Application ID | 202448084578 |
| Invention Field | BIOTECHNOLOGY |
| Date of Application | 05/11/2024 |
| Publication Number | 46/2024 |
Inventors
| Name | Address | Country | Nationality |
|---|---|---|---|
| WU, Chengbin | 6th Floor, Building 2, 4560 Jinke Road Shanghai 201210 CN | U.S.A. | U.S.A. |
| WU, Danqing | 6th Floor, Building 2, 4560 Jinke Road Shanghai 201210 CN | China | China |
| HUANG, Lini | 6th Floor, Building 2, 4560 Jinke Road Shanghai 201210 CN | China | China |
| ZHANG, Amin | 6th Floor, Building 2, 4560 Jinke Road Shanghai 201210 CN | China | China |
| SHUAI, Zhengrong | 6th Floor, Building 2, 4560 Jinke Road Shanghai 201210 CN | China | China |
| ZHANG, Rui | 6th Floor, Building 2, 4560 Jinke Road Shanghai 201210 CN | China | China |
| GONG, Shiyong | 6th Floor, Building 2, 4560 Jinke Road Shanghai 201210 CN | China | China |
| WU, Xuan | 6th Floor, Building 2, 4560 Jinke Road Shanghai 201210 CN | China | China |
Applicants
| Name | Address | Country | Nationality |
|---|---|---|---|
| SHANGHAI EPIMAB BIOTHERAPEUTICS CO., LTD. | 6th Floor, Building 2, 4560 Jinke Road, Pudong New District, Shanghai 201210 CN | China | China |
Specification
Description:AS FILED PDF DOCUMENT , Claims:AS FILED PDF DOCUMENT
Documents
| Name | Date |
|---|---|
| 202448084578-FORM 13 [22-11-2024(online)].pdf | 22/11/2024 |
| 202448084578-POA [22-11-2024(online)].pdf | 22/11/2024 |
| 202448084578-RELEVANT DOCUMENTS [22-11-2024(online)].pdf | 22/11/2024 |
| 202448084578-COMPLETE SPECIFICATION [05-11-2024(online)].pdf | 05/11/2024 |
| 202448084578-DECLARATION OF INVENTORSHIP (FORM 5) [05-11-2024(online)].pdf | 05/11/2024 |
| 202448084578-DRAWINGS [05-11-2024(online)].pdf | 05/11/2024 |
| 202448084578-FIGURE OF ABSTRACT [05-11-2024(online)].pdf | 05/11/2024 |
| 202448084578-FORM 1 [05-11-2024(online)].pdf | 05/11/2024 |
| 202448084578-POWER OF AUTHORITY [05-11-2024(online)].pdf | 05/11/2024 |
| 202448084578-PROOF OF RIGHT [05-11-2024(online)].pdf | 05/11/2024 |
| 202448084578-Sequence Listing in PDF [05-11-2024(online)].pdf | 05/11/2024 |
| 202448084578-Sequence Listing in txt [05-11-2024(online)].txt | 05/11/2024 |
| 202448084578-STATEMENT OF UNDERTAKING (FORM 3) [05-11-2024(online)].pdf | 05/11/2024 |
