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ANTIBODIES TO CD3 AND BCMA, AND BISPECIFIC BINDING PROTEINS MADE THEREFROM

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ANTIBODIES TO CD3 AND BCMA, AND BISPECIFIC BINDING PROTEINS MADE THEREFROM

DIVISIONAL PCT NATIONAL PHASE APPLICATION

Published

date

Filed on 5 November 2024

Abstract

ABSTRACT “ANTIBODIES TO CD3 AND BCMA, AND BISPECIFIC BINDING PROTEINS MADE THEREFROM” High-affinity antibodies recognizing CD3 and B Cell Maturation Factor protein (BCMA) are Provided. Binding sites from humanized anti-CD3 and anti-BCMA antibodies are incorporated into a Fabs-in-Tandem Immunoglobulin format without significant loss of binding affinity, and the resultant bispecific, multivalent binding proteins are able to bind to both CD3 and BCMA simultaneously. Such antibodies, antigen-binding portions thereof, and bispecific FIT-Ig binding proteins are useful for treating cancer.

Patent Information

Application ID202448084578
Invention FieldBIOTECHNOLOGY
Date of Application05/11/2024
Publication Number46/2024

Inventors

NameAddressCountryNationality
WU, Chengbin6th Floor, Building 2, 4560 Jinke Road Shanghai 201210 CNU.S.A.U.S.A.
WU, Danqing6th Floor, Building 2, 4560 Jinke Road Shanghai 201210 CNChinaChina
HUANG, Lini6th Floor, Building 2, 4560 Jinke Road Shanghai 201210 CNChinaChina
ZHANG, Amin6th Floor, Building 2, 4560 Jinke Road Shanghai 201210 CNChinaChina
SHUAI, Zhengrong6th Floor, Building 2, 4560 Jinke Road Shanghai 201210 CNChinaChina
ZHANG, Rui6th Floor, Building 2, 4560 Jinke Road Shanghai 201210 CNChinaChina
GONG, Shiyong6th Floor, Building 2, 4560 Jinke Road Shanghai 201210 CNChinaChina
WU, Xuan6th Floor, Building 2, 4560 Jinke Road Shanghai 201210 CNChinaChina

Applicants

NameAddressCountryNationality
SHANGHAI EPIMAB BIOTHERAPEUTICS CO., LTD.6th Floor, Building 2, 4560 Jinke Road, Pudong New District, Shanghai 201210 CNChinaChina

Specification

Description:AS FILED PDF DOCUMENT , Claims:AS FILED PDF DOCUMENT

Documents

NameDate
202448084578-FORM 13 [22-11-2024(online)].pdf22/11/2024
202448084578-POA [22-11-2024(online)].pdf22/11/2024
202448084578-RELEVANT DOCUMENTS [22-11-2024(online)].pdf22/11/2024
202448084578-COMPLETE SPECIFICATION [05-11-2024(online)].pdf05/11/2024
202448084578-DECLARATION OF INVENTORSHIP (FORM 5) [05-11-2024(online)].pdf05/11/2024
202448084578-DRAWINGS [05-11-2024(online)].pdf05/11/2024
202448084578-FIGURE OF ABSTRACT [05-11-2024(online)].pdf05/11/2024
202448084578-FORM 1 [05-11-2024(online)].pdf05/11/2024
202448084578-POWER OF AUTHORITY [05-11-2024(online)].pdf05/11/2024
202448084578-PROOF OF RIGHT [05-11-2024(online)].pdf05/11/2024
202448084578-Sequence Listing in PDF [05-11-2024(online)].pdf05/11/2024
202448084578-Sequence Listing in txt [05-11-2024(online)].txt05/11/2024
202448084578-STATEMENT OF UNDERTAKING (FORM 3) [05-11-2024(online)].pdf05/11/2024

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