“A Combination of Insecticidal and Fungicidal Agrochemical Composition”

Abstract

ABSTRACT A combination of insecticidal and fungicidal agrochemical composition The present invention relates to a combination of insecticidal and fungicidal agrochemical composition of 4-oxo-1-(pyrimidin-5-ylmethyl)-3-[3-(trifluoromethyl)phenyl]pyrido[1,2-a]pyrimidin-1-ium-2-olate (Compound A), 6-methyl-4-[(E)-pyridin-3-ylmethylideneamino]-2,5-dihydro-1,2,4-triazin-3-one (Compound B) and at least one fungicide (Compound C) demonstrating an effective and synergistic broad spectrum control of insects-pests and fungi. The combination of insecticidal and fungicidal composition of present invention is environmentally safe and improves overall health, yield and vigor of the treated plant and provides complete protection to the crop plants.

Specification

Description:FORM 2
THE PATENTS ACT 1970
(39 of 1970)
&
The Patents Rules, 2003
COMPLETE SPECIFICATION
(See section 10 and rule 13)
1. TITLE OF THE INVENTION: "A Combination of Insecticidal and Fungicidal Agrochemical Composition"
2. APPLICANT:
(a) Name : RAJDHANI PETROCHEMICALS PRIVATE LIMITED
(b) Nationality : INDIAN
(c) Address : 6, LALITA COMPLEX, RASALA ROAD, NAVRANGPURA, AHMEDABAD-380009 Gujarat, India
PROVISIONAL
The following specification describes the invention. þCOMPLETE
The following specification particularly describes the invention and the manner in which it is to be performed.





FIELD OF INVENTION
The present invention relates to a combination of insecticidal and fungicidal agrochemical composition. More specifically, the present invention relates to a combined insecticidal and fungicidal agrochemical composition comprising 4-oxo-1-(pyrimidin-5-ylmethyl)-3-[3-(trifluoromethyl)phenyl]pyrido[1,2-a]pyrimidin-1-ium-2-olate, 6-methyl-4-[(E)-pyridin-3-ylmethylideneamino]-2,5-dihydro-1,2,4-triazin-3-one, and at least one more compound selected from group of fungicides. The present invention further relates to an agrochemical composition that provides a composition with enhanced efficacy for superior pest control, offering thorough protection against both insects and fungus, thereby supporting healthier and more resilient plants.
BACKGROUND OF THE INVENTION
In the field of agriculture, the management of pests and diseases is critical to maintaining crop health and productivity. Various agrochemical compositions have been developed to protect crops against a range of pests and fungal diseases.
The problem of pest resistance in agricultural production is a global problem, and it has always been the focus of attention of agricultural science and technology workers. Chemical control by the use of various chemicals and formulations is an important tool in agriculture for the prevention and control of pests. Insecticides of many types and groups are reported in the literature and a large number are in use, commercially, for control of pests in agriculture. With the continuous use of chemical pesticides to control pests year after year, the increase in the use of pesticides and the unscientific use of pesticides; the resistance to pests has become increasingly serious, and the types of pests that have developed resistance have increased.
At the same time, the high‐intensity use of pesticides has led to a series of problems such as excessive pesticide residues in agricultural products, environmental pollution, and increased costs for farmers to use drugs, which is not conducive to the sustainable development of agriculture.
One such prior art is WO2023047294A1 outlines a novel pesticidal composition that includes at least one agrochemically approved excipient, an effective quantity of elemental sulfur, and an effective amount of 4-oxo-1-(pyrimidin-5-ylmethyl)-3-[3-(trifluoromethyl)phenyl]pyrido[1,2-a]pyrimidin-1-ium-2-olate or its salts or derivatives. The invention involves treating plants, crops, propagation materials, seeds, seedlings, and soil with a pesticidal composition containing elemental sulfur, 4-oxo-1-(pyrimidin-5-ylmethyl)-3-[3-(trifluoromethyl)phenyl]pyrido[1,2-a]pyrimidin-1-ium-2-olate or its derivatives, and an agrochemically acceptable excipient.
Similarly, CN102388906 discloses a compound insecticide made of clothianidin and 6-methyl-4-[(E)-pyridin-3-ylmethylideneamino]-2,5-dihydro-1,2,4-triazin-3-one, which is specifically employed in application research to prevent rice plant hopper. This composition, lack any fungicidal properties, requiring farmers to apply separate fungicides to manage diseases, thus increasing the number of applications, time and costs associated with crop management.
US9538753 discloses a synergistic fungicidal mixture with strobilurin fungicides that includes (a) a compound of Formula I and (b) at least one fungicide from the group consisting of a strobilurin, such as methyl N-[2-[[1-(4-chlorophenyl)pyrazol-3-yl]oxymethyl]phenyl]-N-methoxycarbamate , methyl (E)-2-[2-[6-(2-cyanophenoxy)pyrimidin-4-yl]oxyphenyl]-3-methoxyprop-2-enoate etc; and a succinate dehydrogenase inhibitor (SDHI), such as benzovindiflupyr.
The active ingredients known from the literature have certain disadvantages such as insufficient control efficacy, restriction of its use due to the appearance of drug-resistant pathogenic fungi, phytotoxicity and contamination to plants, or toxicity to human beings, beasts, fishes and the like. Hence, there is a long felt need to develop novel and effective combinations for controlling the harmful pests in plants that demonstrate high efficacy, are environmentally safe and can be advantageously formulated.
The insecticidal composition currently in use is not that effective; and due to their prolonged indiscriminate and non-judicious use, some pests have developed resistance to such commonly used pesticides. Their use is thereby becoming increasingly difficult.
Therefore, there is an urgent need to develop new methods and formulations for controlling these harmful pests. Therefore, there is a need to provide a composition which overcomes some of the existing problems and can be prepared easily without much complex manufacturing process.
By offering a more stable solution, the present invention addresses the limitations of previous technologies and promotes better agricultural productivity.
OBJECT OF THE INVENTION
The principal object of the present invention is to provide a combination of insecticidal and fungicidal agrochemical composition.
Another object of the present invention is to provide a combination of insecticidal and fungicidal agrochemical insecticidal composition comprising 4-oxo-1-(pyrimidin-5-ylmethyl)-3-[3-(trifluoromethyl)phenyl]pyrido[1,2-a]pyrimidin-1-ium-2-olate, 6-methyl-4-[(E)-pyridin-3-ylmethylideneamino]-2,5-dihydro-1,2,4-triazin-3-one, and at least one more compound selected from group of fungicides, and method of preparation thereof.
Yet another object of the present invention is to provide a combination of insecticidal and fungicidal agrochemical composition that increases pests and disease control efficiency.
Yet another object of the present invention is to provide a combination of insecticidal and fungicidal agrochemical composition which enhances plant's resilience to abiotic stress factors, while maintaining effective pest control.
Further object of the present invention is to provide a combination of insecticidal and fungicidal agrochemical composition which remains stable during extended storage, ensuring reliable performance across diverse conditions.
Another object of the present invention is to provide a method of preparing a stable and non-phytotoxic formulation which improves overall health, and yield of the treated plant and which is environmentally safe.

SUMMARY OF THE INVENTION
The present invention relates to a combination of insecticidal and fungicidal agrochemical composition. More specifically, the present invention relates to a combination of insecticidal and fungicidal agrochemical composition comprising 4-oxo-1-(pyrimidin-5-ylmethyl)-3-[3-(trifluoromethyl)phenyl]pyrido[1,2-a]pyrimidin-1-ium-2-olate, 6-methyl-4-[(E)-pyridin-3-ylmethylideneamino]-2,5-dihydro-1,2,4-triazin-3-one, and at least one more compound selected from a group of fungicides.
The combination of insecticidal and fungicidal agrochemical composition of the present invention is formulated as Capsule suspension (CS), Dispersible concentrate (DC), Dustable powder (DP), Powder for dry seed treatment (DS), Emulsifiable concentrate (EC), Emulsifiable granule (EG), Emulsion water-in-oil (EO), Emulsifiable powder (EP), Emulsion for seed treatment (ES), Emulsion oil-in-water (EW), Flowable concentrate for seed treatment (FS), Granules (GR), Micro-emulsion (ME), Oil-dispersion (OD), Oil miscible flowable concentrate (OF), Oil miscible liquid (OL), Oil dispersible powder (OP), Suspension concentrate (SC), Suspension concentrate for direct application (SD), Suspo-emulsion (SE), Water soluble granule (SG), Soluble concentrate (SL), Spreading oil (SO), Water soluble powder (SP), Water soluble tablet (ST), Ultra-low volume (ULV) suspension, Tablet (TB), Ultra-low volume (ULV) liquid, Water dispersible granules (WDG/WG), Wettable powder (WP), Water dispersible powder for slurry seed treatment (WS), Water dispersible tablet (WT), a mixed formulation of CS and SC (ZC) or A mixed formulation of CS and SE (ZE), a mixed formulation of CS and EW (ZW).
The process for preparing the present combination of insecticidal and fungicidal composition can be modified accordingly by any person skilled in the art based on the knowledge of the manufacturing the formulation. However, all such variation and modification is still covered by the scope of present invention.
The present invention is a combination of insecticidal and fungicidal agrochemical composition formulated to increase pests and disease control efficiency. The present invention also helps in studying the synergism and benefits on rice and mango crop. The present invention which is a combination of insecticidal and fungicidal agrochemical composition is environmentally safe also enhances plant's resilience to abiotic stress factors, while maintaining effective pest control. Therefore, the combination of insecticidal and fungicidal agrochemical composition results in a method of preparing a stable and non-phytotoxic formulation which improves overall health, and yield of the treated plant.

DETAILED DESCRIPTION OF THE INVENTION
Before explaining the present invention in detail, it is to be understood that the invention is not limited in its application to the details of the parts illustrated. The invention is capable of other embodiments, as described above and of being practiced or carried out in a variety of ways. It is to be understood that the phraseology and terminology employed herein is for the purpose of description and not to limitation. The invention may have various embodiments and they may be performed as described in the following pages of the complete specification.
The terms and words used in the following description are not limited to the bibliographical meanings, but, are merely used by the inventors to enable a clear and consistent understanding of the invention. Accordingly, it should be apparent to those skilled in the art that the following description of exemplary embodiments of the present invention are provided for illustration purpose only and not for the purpose of limiting the scope of the invention.
It is to be understood that the singular forms "a," "an," and "the" include plural reference unless the context clearly dictates otherwise.
Features that are described and/or illustrated with respect to one embodiment may be used in the same way or in a similar way in one or more other embodiments and/or in combination with or instead of the features of the other embodiments.
It should be emphasized that the term "comprises/comprising" when used in this specification is taken to specify the presence of stated features, steps or components but does not preclude the presence or addition of one or more other features, steps, components or groups thereof.
The term 'plants' as used herein, refers to all physical parts of a plant, including seeds, seedlings, saplings, roots, tubers, stems, stalks, foliage and fruits. The term "plant" is to be understood as including wild type plants and plants, which have been modified by either conventional breeding, or mutagenesis or genetic engineering, or by a combination thereof.
The term "crop" refers to both, growing and harvested crops.
The term "insects" as used herein, includes all organisms in the class "Insecta."
The term "fungi" as used herein, includes all organisms in the class of "Fungi."
The term "animal pest" includes arthropods, gastropods, and nematodes. Preferred animal pests according to the invention are arthropods, preferably insects and arachnids, in particular insects. Insects, which are of particular relevance for crops, are typically referred to as crop insect pests.
The term "insecticidal" and/or "fungicidal" as used herein, refers to the ability of an insecticide and/or fungicide to increase mortality or inhibit growth rate of insects/fungi.
To "control" or "controlling" pests means to inhibit, through a toxic effect, the ability of pests to survive, grow, feed, and/or reproduce, or to limit pest related damage or loss in crop plants. To "control" pests may or may not mean killing the pests, although it preferably means killing the pests.
The term "health of a plant" or "plant health" is defined as a condition of the plant and/or its products. As a result of the improved health, yield, plant vigor, quality and tolerance to abiotic or biotic stress are increased.
"Yield" is to be understood as any plant product of economic value that is produced by the plant such as grains, fruits in the proper sense, vegetables, nuts, grains, seeds, wood (e.g. in the case of silviculture plants) or even flowers (e.g. in the case of gardening plants, ornamentals).
"Increased yield" of a plant, in particular of an agricultural, silvicultural and/or horticultural plant means that the yield of a product of the respective plant is increased by a measurable amount over the yield of the same product of the plant produced under the same conditions, but without the application of the composition according to the invention.
The present invention provides a synergistic agrochemical composition comprising
1. Compound A-4-oxo-1-(pyrimidin-5-ylmethyl)-3-[3 (trifluoromethyl)phenyl]pyrido[1,2-a]pyrimidin-1-ium-2-olate
2. Compound B - 6-methyl-4-[(E)-pyridin-3-ylmethylideneamino]-2,5-dihydro-1,2,4-triazin-3-one
3. Compound C - at least one more compounds selected from group of fungicides.
Sr. No. Ingredient Concentration range (w/w %)
1. Compound A 2 to 8
2. Compound B 12 to 40
3. Compound C 5 to 25
Compound A is Triflumezopyrim, 4-oxo-1-(pyrimidin-5-ylmethyl)-3-[3-(trifluoromethyl)phenyl]pyrido[1,2-a]pyrimidin-1-ium-2-olate is a low-toxic insecticide which is typically used in crops like rice.

It is designed specifically target sap-feeding pests while minimizing environmental impact. It impacts the nicotinic acetylcholine receptors in insects, causing paralysis and death.
.
Compound B is Pymetrozine, 6-methyl-4-[(E)-pyridin-3-ylmethylideneamino]-2,5-dihydro-1,2,4-triazin-3-one is a low-toxic insecticide which is typically used in crops like rice, cotton etc.

This insecticide targets sap-feeding pests, such as aphids and whiteflies, by disrupting their feeding behavior. It works by affecting the nervous regulation of feeding, causing the insects to stop feeding and eventually die.
Because of its high degree of selectivity, minimal toxicity to mammals, and safety for fish, birds, and non-target arthropods, the chemical seems to hold significant promise for use in integrated pest management (IPM) programs.
Compound C is at least one more compound selected from a group of fungicide and is broad spectrum fungicide which is effective against a wide range of fungal diseases.
Compound C is selected from group consisting of
C1, Pyraclostrobin: methyl N-[2-[[1-(4-chlorophenyl)pyrazol-3-yl]oxymethyl]phenyl]-N-methoxycarbamate,
C2, Azoxystrobin: methyl (E)-2-[2-[6-(2-cyanophenoxy)pyrimidin-4-yl]oxyphenyl]-3-methoxyprop-2-enoate,
C3, Trifloxystrobin: methyl (2Z)-2-methoxyimino-2-[2-[[(E)-1-[3-(trifluoromethyl)phenyl]ethylideneamino]oxymethyl]phenyl]acetate,
C4, Picoxystrobin: methyl (E)-3-methoxy-2-[2-[[6-(trifluoromethyl)pyridin-2-yl]oxymethyl]phenyl]prop-2-enoate,
C5, Kresoxim Methyl: methyl (2E)-2-methoxyimino-2-[2-[(2-methylphenoxy)methyl]phenyl]acetate,
C6, Thifluzamide: N-[2,6-dibromo-4-(trifluoromethoxy)phenyl]-2-methyl-4-(trifluoromethyl)-1,3-thiazole-5-carboxamide,
C7, Fluxapyroxad: 3-(difluoromethyl)-1-methyl-N-[2-(3,4,5-trifluorophenyl)phenyl]pyrazole-4-carboxamide,
C8, Validamycin: (2R,3R,4S,5S,6R)-2-[(1R,2R,3S,4S,6R)-2,3-dihydroxy-6-(hydroxymethyl)-4-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino]cyclohexyl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol.
The present invention optionally comprises agrochemically acceptable excipients including, but not limited to, dispersing agents, anti-freezing agent, anti-foam agent, wetting agents, suspension aid and carriers, anti-microbial agent, thickener, colorants, quick coating agent or sticking agents (also referred to as "stickers" or "binders"), polymers, disintegrating agent, oil additive, buffering agent, and solvents.
However, those skilled in the art will appreciate that it is possible to utilize additional agrochemically acceptable excipients without departing from the scope of the present invention. The agrochemically acceptable excipient can be in the range from 0.1% to 99% of the total weight of the composition.
The amount of a composition according to the invention to be applied, will depend on various factors, such as the subject of the treatment, such as, for example plants, soil or seeds; the type of treatment, such as, for example spraying, dusting or seed dressing; the purpose of the treatment, such as, for example prophylactic or therapeutic disease control; in case of disease control the type of fungi to be controlled or the application time. This amount of the combinations of the present invention to be applied can be readily deduced by a skilled agronomist.
The combination of insecticidal and fungicidal agrochemical composition of the present invention is formulated as Capsule suspension (CS), Dispersible concentrate (DC), Dustable powder (DP), Powder for dry seed treatment (DS), Emulsifiable concentrate (EC), Emulsifiable granule (EG), Emulsion water-in-oil (EO), Emulsifiable powder (EP), Emulsion for seed treatment (ES), Emulsion oil-in-water (EW), Flowable concentrate for seed treatment (FS), Granules (GR), Micro-emulsion (ME), Oil-dispersion (OD), Oil miscible flowable concentrate (OF), Oil miscible liquid (OL), Oil dispersible powder (OP), Suspension concentrate (SC), Suspension concentrate for direct application (SD), Suspo-emulsion (SE), Water soluble granule (SG), Soluble concentrate (SL), Spreading oil (SO), Water soluble powder (SP), Water soluble tablet (ST), Ultra-low volume (ULV) suspension, Tablet (TB), Ultra-low volume (ULV) liquid, Water dispersible granules (WDG/WG), Wettable powder (WP), Water dispersible powder for slurry seed treatment (WS), Water dispersible tablet (WT), a mixed formulation of CS and SC (ZC) or A mixed formulation of CS and SE (ZE), a mixed formulation of CS and EW (ZW).
In a preferred embodiment, the synergistic agrochemical composition is formulated as a Suspension concentrate (SC) and Water dispersible granules (WDG/WG).
The inactive excipients used in various formulations are as follows:
A. Lists of inactive excipients used in Suspension Concentrate (SC) formulation:
The Suspension Concentrate formulation (SC) of the present invention comprises agrochemically acceptable excipients including, but not limited to, wetting agent(s), wetting-spreading-penetrating agent(s), dispersing agent(s), suspending agent(s), antifoaming agent(s), antifreezing agent(s), preservative(s), thickener(s) and humectants(s).
The wetting agent of SC is selected from, but not limited to, ethylene oxide/propylene oxide (EO/PO) block copolymer, polyarylphenyl ether phosphate, polyalkoxylated butyl ether, ethoxylated fatty alcohol, sodium dioctyl sulfosuccinate, sodium lauryl sulfate and sodium dodecyl benzene sulfonate, alkyl diphenyl sulfonates, sodium isopropyl naphthalene sulfonate, alkyl naphthalene sulfonate. Ethoxylated alcohol includes natural fatty alcohol (lauryl alcohol ethoxylate, lauryl alcohol alkoxylate), synthetic alcohol ethoxylate (tridecyl alcohol ethoxylate, 2-ethyl hexanol, 2-propylheptanol, isodecyl alcohol or mixture thereof.

The wetting-spreading-penetrating agent of SC is selected from, but not limited totrisiloxane ethoxylate, heptamethyl trisiloxane, modified form includes polyalkyleneoxide modified heptamethyl trisiloxane,polyether modified polysiloxane, polyalkyleneoxide modified trisiloxane, polyalkyleneoxide modified polydimethylsiloxane, may be liquid or powder form or mixture thereof.
The dispersing agent of SC is selected from, but not limited to, Naphthalenesulfonic acid, sodium salt condensate with formaldehyde, alkylated naphthalene sulfonate, sodium salt, sodium salt of naphthalene sulfonate condensate, sodium ligno sulfonate, sodium polycarboxylate, EO/PO based copolymer, phenol sulfonate, sodium methyl oleoyl taurate, styrene acrylic acid copolymer, propylene oxide-ethylene oxide-copolymer, polyethylene glycol 2,4,6-tristyrylphenyl ether, tristyrylphenol-polyglycol ether-phosphate, tristyrylphenole with 16 moles EO, tristyrylphenol-polyglycol ether-phosphate, oleyl-polyglycol ether with ethylene oxide, tallow fatty amine polyethylene oxide, nonylphenol polyglycol ether with 9-10 moles ethylene oxide or mixture thereof.
The suspending agent of SC is selected from, but not limited to aluminum magnesium silicate, bentonite clay, silica, attapulgite clay or mixture thereof.
The antifoaming agent of SC is selected from but not limited to silicone antifoam emulsion, dimethyl siloxane, polydimethyl siloxane, vegetable oil based antifoam, tallow based fatty acids or mixture thereof.
The anti-freezing agent of SC is selected from but not limited to ethylene glycol, propane diols, glycerin or the urea, glycol (monoethylene glycol, diethylene glycol, polypropylene glycol, polyethylene glycol), glycerin, urea, magnesium sulfate heptahydrate, sodium chloride or mixture thereof.
The preservatives of SC is selected from, but not limited to, 1,2-benzisothiazolin-3(2H)-one, sodium salt, sodium benzoate, 2-bromo-2-nitropropane-1,3-diol, formaldehyde, sodium o-phenyl phenate, 5-chloro-2-methyl-4-isothiazolin-3-one & 2-methyl-4-isothiazolin-3-one or mixture thereof.
The thickeners of SC is selected from, but not limited to, xanthan gum, PVK, carboxymethyl celluloses, polyvinyl alcohols, gelatin, sodium carboxymethylcellulose, hydroxyethyl cellulose, sodium polyacrylate, modified starch, acacia gum or mixture thereof.
The humectants of SC is selected from, but not limited to, urea, humic acid, glycerol, lactose or mixture thereof.
Manufacturing process for Suspension Concentrate (SC) formulation:
Step 1: Gel preparation: A required quantity of water is charged to a vessel which is equipped with a high shear stirrer whilst the agitation is initiated. A required amount of preservative(s) is/are added and mixed to form a homogenous mixture. A required amount of thickener(s) is/are added and mixed vigorously to achieve wetness.
Step 2: A required quantity of water is charged to a vessel which is equipped with a bulk agitator and a high shear homogenizer; initiated the agitation. Further, a required amount of an anti freezing agent(s) is/are added and mixed to achieve uniformity. Moreover, the antifoaming agent(s) is/are added whilst ensuring that it is well dispersed. The wetting and dispersing agent(s) is/are added and mixed to achieve uniformity whilst ensuring that the dispersing agent(s) is/are fully dispersed.
Step 3: The active ingredients are added and the agitation of the vessel contents are continued until all the compounds get dissolved. The pre-mix is milled through a colloid mill and subsequently through a dyno mill to meet the specified particle size.
Step 4: The remaining antifoaming agent(s) is/are added to this SC mill base to a vessel which is equipped with the bulk agitator and mixed to achieve uniformity. The required amount of 2% aqueous pre-gel and suspending agent(s) is/are added and the agitation is continued until the formulation is homogeneous and has reached the target viscosity.
Step 5: The final product is submitted for QC's approval.
Step 6: The material is packed in its required package sizes when received approval.
B. Lists of inactive excipients used in WG (Wettable Granule)/WDG (Water Dispersible Granule) formulation:

The WG (Wettable Granule)/WDG (Water Dispersible Granule) formulation of the present invention comprises agrochemically acceptable excipients including, but not limited to, dispersing agent(s), wetting agent(s), antifoaming agent(s), carrier(s) and disintegrating agent(s).
The dispersing agent of WG/WDG is selected from, but not limited to alkylnaphthalene sulfonate sodium salt, sodium polycarboxylate, naphthalenesulfonic acid, sodium salt condensates with formaldehyde, polyalcoxylated alkylphenol, sodium polycarboxylate, naphthalenesulfonic acid formaldehyde condensate, methylnaphthalene-formaldehyde-condensate sodium salt, naphthalene condensates, polyacrylates copolymer and phosphate esters, calcium lignosulfonate, sodium lignosulfonates, lignin sulfonate sodium salt, Sodium Methyl Oleoyl Taurate, or mixture thereof.

The wetting agent of WG/WDG is selected from, but not limited to sodium N-methyl-N-oleoyl taurate, alkylated naphthalene sulfonate, sodium salt, mixture of isomers of dibutylnaphthalene sulphonic acid sodium salt, sodium isopropylnaphthalenesulphonate, Sodium isobutyl naphthalene sulfonate, sodium Lauryl sulfate, dioctyl sulfate, alkyl naphthalene sulfonates, phosphate esters, sulphosuccinates and non-ionic such as tridecyl alcohol ethoxylate, alkyl or alkaryl sulfonates such as alkylbenzene sulfonates, alpha olefin sulfonate and alkyl naphthalene sulfonates, ethoxylated or non-ethoxylated alkyl or alkaryl carboxylates, alkyl or alkaryl phosphate esters, alkyl polysaccharide, di or mono alkyl sulfosuccinate derivatives, alpha olefin sulfonates, alkyl naphthalene sulfonates, dialkyl sulphosuccinates, butyl, dibutyl, isopropyl and di-isopropyl naphthalene sulfonate salts, C12 alkyl benzene sulfonate or C10-C16 alkyl benzene sulfonate, organosilicons surfactants includes trisiloxane ethoxylate, polydimethylsiloxane, polyoxyethylene methyl polysiloxane, polyoxyalkylene methyl polysiloxane, polyether polymethyl siloxane copolymer, trisiloxaneheptamethyl, Polyalkyleneoxide modified heptamethyl trisiloxane, polyether modified polysiloxane, may or may not be in modified form, may be liquid or powder form or mixture thereof.
The antifoaming agent of WG/WDG is selected from, but not limited to polydimethylsiloxane.
The carrier of WG/WDG is selected from, but not limited to china clay, silica, lactose anhydrous, ammonium sulfate, sodium sulfate anhydrous, corn starch, urea, EDTA, urea formaldehyde resin, diatomaceous earth, kaolin, bentonite, kieselguhr, fuller's earth, attapulgite clay, bole, loess, talc, chalk, dolomite, limestone, lime, calcium carbonate, powdered magnesia, magnesium oxide, magnesium sulphate, sodium chloride, gypsum, calcium sulphate, pyrophyllite, silicates and silica gels; fertilizers such as, for example, ammonium sulphate, ammonium phosphate, ammonium nitrate and urea; natural products of vegetable origin such as, for example, grain meals and flours, bark meals, wood meals, nutshell meals and cellulosic powders; and synthetic polymeric materials such as, for example, ground or powdered plastics and resins, bentonites, zeolites, titanium dioxide, iron oxides and hydroxides, aluminium oxides and hydroxides, or organic materials such as bagasse, charcoal, or synthetic organic polymers, or mixture thereof.
The disintegrating agent of WG/WDG is selected from, but not limited to citric acid, succinic acid or sodium bicarbonate, or mixture thereof.
Manufacturing process for WG (Wettable Granule)/WDG (Water Dispersible Granule) formulation:
Step 1: An exact weight of active ingredients is considered and a required quantity of binder(s) and surfactant(s) is/are added in the blender and mixed to achieve a complete homogenization.
Step 2: The homogenized mixture is milled to achieve required wet sieve and post blended to attain homogeneity.
Step 3: The above described homogenous material is passed through an extruder for granulation to achieve granular of require size.
Step 4: The wet granules are transferred through fluidized bed drier to remove excess moisture.
Step 5: The wet granules are further transferred to vibro shifter and further graded using vibrator screens.
Step 6: The final material is collected from the vibro shifter into drum.
Step 7: The sample is sent to QC for an approval.
Step 8: The material is transferred into the different size of drums when received an approval from QC.
EXAMPLES
The present invention has been described with reference to specific embodiment which is merely illustrative and not intended to limit the scope of the invention as defined in the present complete specification.
Biological Examples:
The combination of insecticidal and fungicidal pesticide action of the inventive mixtures can be demonstrated by the experiments below. A synergistic effect exists wherever the action of a combination (ready-mix) or tank mix of active ingredient is greater than the sum of the action of each of the compounds alone. Therefore, a synergistically effective amount or an effective amount of a synergistic composition or combination is an amount that exhibits greater pesticide activity than the sum of the pesticide activities of the individual compounds.
In the field of agriculture, it is often understood that the term "synergy" is as defined by Colby S.R. in an article entitled " Calculation of the synergistic and antagonistic responses of herbicide combinations" published in the journal Weeds, 1967, 15, p.20-22, incorporated herein by reference in its entirety. The action expected for a given combination of two or three active compounds can be calculated as follows:

The objective of the present studies was to study the synergism and benefits on rice and mango crop.

Example 1: Synergism
Crop : Rice
Location : Bhandara, Maharashtra
Number of Treatments: six including untreated checks.
Plot size : 10 m x 5 m.
Crop stage : 64 days after transplanting.
Method of application: foliar spray with battery operated backpack sprayer
Water volume : 450 liter per hectare

Observation Methods:
Brown Plant Hopper (BPH) control (%): count the number of live BPH per hill. Record the observations from 20 hills per plot. The data on average number of BPH per hill used to calculate BPH (%) as observed value. Apply Colby formula to calculate expected control and thereby synergism.



Composition of Compound A 6%+ Compound B 30%+ Compound C1 20% WDG
[T1 of Ex. 1]
Chemical Composition Function content (%,w/w)
Compound A Compound A 6.00
Compound B Compound B 30.00
Compound C1 Compound C1 20.00
Sodium lignosulphonate Dispersing agent 7.00
polyacrylate copolymer Dispersing agent 3.00
Sodium isopropyl naphthalene sulfonate Wetting agent 5.00
Polydimethylsiloxane Antifoaming Agent 1.00
Corn Starch Carrier 12.00
China clay Carrier 16.00
Total 100.00
active ingredient on 100% purity basis



Storage Stability: Compound A 6%+ Compound B 30%+ Compound C1 20% WDG
[T1 of Ex. 1]
Laboratory storage stability for 14 days [T1 of Ex. 1]
Parameters Specification Initial At 54±2 0C At 0±2 0C
Compound A content (%, w/w) 5.70 to 6.60 6.32 6.31 6.32
Compound B content (%, w/w) 28.50 to 31.50 31.25 31.22 31.25
Compound C1 content (%, w/w) 19.00 to 21.00 20.64 20.59 20.64
Compound A suspensibility (%) 70 91.82 91.45 91.79
Compound B suspensibility (%) 70 89.91 89.23 89.89
Compound C1 suspensibility (%) 70 92.63 92.45 92.60
pH range (1% aq. Suspension) 5 to 9 8.10 8.15 8.12
Particle size (micron) D90<10 8.1 8.2 8.1
Persistent foam ml (after 1 minute) max. 60 22 25 20

Room temperature storage stability up to 12 months [T1 of Ex. 1]
Parameters Specification 1 month 6 month 12 month
Compound A tech. content (%, w/w) 5.70 to 6.60 6.32 6.31 6.31
Compound B tech. content (%, w/w) 28.50 to 31.50 31.25 31.24 31.22
Compound C1 tech. content (%, w/w) 19.00 to 21.00 20.64 20.61 20.59
Compound A suspensibility (%) 70 91.82 91.87 91.82
Compound B suspensibility (%) 70 89.91 89.88 89.87
Compound C1 suspensibility (%) 70 92.63 92.61 92.57
pH range (1% aq. Suspension) 5 to 9 8.11 8.12 8.15
Particle size (micron) D90<10 8.1 8.2 8.3
Persistent foam ml (after 1 minute) max. 60 22 25 25

The composition of Compound A 6%+ Compound B 30%+ Compound C1 20% WDG meets the all inhouse specifications for storage stability studies in laboratory (at 54±2 C & At 0±2 C for 14 days) and room temperature (for 12 months).


Manufacturing process for 100 kg batch of Compound A 6%+ Compound B 30%+ Compound C1 20% WDG [T1 of Ex. 1]
Step 1 Charge the 16 kg China clay, 12.0 kg Corn starch, 0.5 kg polydimethyl siloxane antifoam, 5 kg of Sodium isopropyl naphthalene sulfonate, 3 kg polyacrylate copolymer and 7.0 kg of Sodium lignosulphonate blend into a ribbon or premix blender and homogenize for 30 minutes.
Step 2 Now charge 6.0 kg Compound A technical, 30 kg Compound B technical and 20 kg Compound C1 technical and again homogenize for 30 minutes and now this Pre-blended material was then grinded through Jet
Step 3 mill/ air classifier mills. Finely grinded material was blended in post blender till it becomes homogeneous. (for approx 1.5 hr)
Step 4 Dough was passed through extruder to get granules of required size.
Step 5 Wet granules are passed through Fluidized bed drier to remove 10 kg extra water added and further graded using vibrating screens.
Step 6 Final product was sent for QC approval.
Step 7 After approval material was packed in required pack sizes.

Table 1: Treatment details [Ex. 1]
Sr.no. Treatment compositions Dose (gram actives per hectare)
T1 Compound A 6%+ Compound B 30%+ Compound C1 20% WDG 22.5+112.5+75
T2 Compound A 10.26% (10% w/v) SC 24
T3 Compound B 50% WG 140
T4 Compound C1 20% WG 96
T5 Dinotefuran 10%+ Compound B 30%+ Compound C1 20% WG 37.5+112.5+75
T6 Untreated Check (UTC) -
T1 are present composition and T5 are prior art whereas T2 to T4 are market product.
Table 2: Synergistic control of Rice BPH [Ex. 1]
S.No. BPH Control (%)
3 DAA 10 DAA 14 DAA
Observed Expected Colby's ratio Observed Expected Colby's ratio Observed Expected Colby's ratio Increase in control over T5
T1 99.93 87.98 1.14 97.82 80.61 1.21 92.38 67.24 1.37 22.02
T2 64.35 - - 56.83 - - 46.38 - - -
T3 60.17 - - 50.17 - - 35.43 - - -
T4 15.38 - - 9.87 - - 5.37 - - -
T5 93.76 - - 87.28 - - 70.36 - - -
T6 0.00 - - 0.00 - - 0.00 - - -
Abbreviation: DAA - days after application
Conclusion: The present composition of treatment of Compound A 6%+Compound B 30%+Compound C1 20% WDG provides synergistic control of BPH on 3rd, 10th and 14th DAA. The present composition also provides 22% higher control as compared to known prior art (T5) on 14th day. At last, the Colby's ratio observed was >1 which means strong synergism, when compared with known combinations and market products.


Example 2: Control of Rice Hoppers and Diseases
Crop : Rice
Location : Kurud, Dhamtari, Chhattisgarh
Number of Treatments: 23
Plot size : 7 m x 5 m.
Crop stage : 90 days after transplanting.
Method of application: foliar spray with battery operated backpack sprayer
Water volume : 500 liter per hectare

Observation Methods:
Rice Hoppers (BHP and WBPH) control (%): as per example 1. BHP-brown plant hopper and WBPH-white backed plant hopper.

Sheath blight (caused by Rhizoctonia solani) control (%):
Observation was recorded on disease severity in each treatment before and at 10 days after spray. The observations of severity of sheath blight disease were recorded using 0-9 grade (SES, IRRI 1996). Twenty randomly selected hills were scored as per scale. The percent disease index (PDI) of plants was calculated by the following formula.




Sheath blight disease Grading (0-9 scale) : [Ex-2]
Grade Symptoms
0 No incidence
1 Less than 1% sheath area infected
3 1-5% sheath area infected
5 6-25% sheath area infected
7 26-50% sheath area infected
9 51-100% sheath area infected

Grain discoloration (%): Count the number of healthy and diseased grains per panicle. Record the observations from 10 panicles randomly selected per plot. Calculate % grain discoloration and % disease control.

Composition of Compound A 4%+ Compound B 24%+ Compound C2 16% WDG
[T2 of Ex. 2]
Chemical Composition Function content (%,w/w)
Compound A Compound A 4.00
Compound B Compound B 24.00
Compound C2 Compound C2 16.00
Sodium polycarboxylate Dispersing agent 6.00
Sodium Methyl Oleoyl Taurate Dispersing agent 4.00
Sodium isobutyl naphthalene sulfonate Wetting agent 5.00
Polydimethylsiloxane Antifoaming Agent 1.00
Corn Starch Carrier 15.00
China clay Carrier 25.00
Total 100.00
active ingredient on 100% purity basis


Storage Stability: Compound A 4%+ Compound B 24%+ Compound C2 16% WDG
Laboratory storage stability for 14 days
Parameters Specification Initial At 54±2 0C At 0±2 0C
Compound A content (%, w/w) 3.80 to 4.40 4.21 4.18 4.21
Compound B content (%, w/w) 22.80 to 25.20 24.30 24.27 24.30
Compound C2 content (%, w/w) 15.20 to 16.80 16.42 16.38 16.42
Compound A suspensibility (%) 70 89.69 89.45 89.65
Compound B suspensibility (%) 70 91.23 91.05 91.19
Compound C2 suspensibility (%) 70 96.89 96.85 96.87
pH range (1% aq. Suspension) 5 to 9 8.12 8.14 8.11
Particle size (micron) D90<10 7.9 8.1 8
Persistent foam ml (after 1 minute) max. 60 20 23 21

Room temperature storage stability up to 12 months
Parameters Specification 1 month 6 month 12 month
Compound A content (%, w/w) 3.8 to 4.4 4.21 4.2 4.18
Compound B content (%, w/w) 22.8 to 25.2 24.30 24.29 24.27
Compound C2 content (%, w/w) 12.35 to 13.65 16.42 16.40 16.38
Compound A suspensibility (%) 70 89.65 89.25 89.11
Compound B suspensibility (%) 70 91.19 90.89 90.45
Compound C2 suspensibility (%) 70 96.89 96.85 96.82
pH range (1% aq. Suspension) 5 to 9 8.12 8.13 8.15
Particle size (micron) D90<10 7.9 8.1 8.2
Persistent foam ml (after 1 minute) max. 60 22 24 24
The composition of Compound A 4%+ Compound B 24%+ Compound C2 16% WDG meets the all inhouse specifications for storage stability studies in laboratory (at 54±2 C & At 0±2 C for 14 days) and room temperature (for 12 months).

Manufacturing process for 100 kg batch of Compound A 4%+ Compound B 24%+ Compound C2 16% WDG [T2 of Ex. 2]
Step 1 Charge the 25 kg China clay, 15.0 kg Corn starch, 0.5 kg polydimethylsiloxane antifoam, 6 kg of Sodium isobutyl naphthalene sulfonate, 4 kg Sodium methyl oleoyl taurate blend into a ribbon or premix blender and homogenization for 30 minutes.
Step 2 Now charge 4.0 kg Compound A technical, 24 kg Compound B technical and 16 kg Compound C2 technical and again homogenize for 30 minutes and now this Pre-blended material was then grinded through Jet mill/ air classifier mills. Finely grinded material was blended in post blender till it becomes homogeneous. (for approx 1.5 hr)
Step 3 Finely grinded powder was mixed with 10 kg of water having 0.5 kg polydimethylsiloxane antifoam to form extrudable dough.
Step 4 Dough was passed through extruder to get granules of required size.
Step 5 Wet granules are passed through Fluidized bed drier to remove 10 kg extra water added and further graded using vibrating screens.
Step 6 Final product was sent for QC approval.
Step 7 After approval material was packed in required pack sizes.

Table 3: Treatment details
Sr.no. Treatment compositions Dose (gram actives per hectare)
T1 Compound A 6.25%+ Compound B 37.5%+ Compound C3 20% WDG 20+120+64
T2 Compound A 4%+ Compound B 24%+ Compound C2 16% WDG 20+120+80
T3 Compound A 2.5%+ Compound B 15%+ Compound C4 7.5% SC 20+120+60
T4 Compound A 2%+ Compound B 12%+ Compound C5 20% SC 20+120+200
T5 Compound B 37.5%+ Compound C3 20% WDG 120+64
T6 Compound B 24%+ Compound C2 16% WDG 120+80
T7 Compound B 15%+ Compound C4 7.5% SC 120+60
T8 Compound B 12%+ Compound C5 20% SC 120+200
T9 Compound A 6.25%+ Compound C3 20% WDG 20+64
T10 Compound A 4%+ Compound C2 16% WDG 20+80
T11 Compound A 2.5%+ Compound C4 7.5% SC 20+60
T12 Compound A 2%+ Compound C5 20% SC 20+200
T13 Compound A 6.25%+ Compound B 37.5% WG 20+120
T14 Compound A 10.6% (10% w/v) SC 20
T15 Compound B 50% WG 120
T16 Compound C3 25% WG 64
T17 Compound C2 25% SC 80
T18 Compound C4 25% SC 60
T19 Compound C5 50% SC 200
T20 Compound A 1%+Sulphur 60% WG 25+1500
T21 Compound A 3.7%+Tebuconazole 28.17 %+Tricyclazole 45% WG 25+187.5+300
T22 Compound B 7.5%+ Compound C2 12%+Tricyclazole 22.5% WDG 120+75+225
T23 Untreated Check (UTC) -

T1 to T4 are present compositions whereas T20 to T22 are known compositions.

Table 4: Control of Rice Hoppers (BPH+WBPH), sheath blight and grain discoloration
Sr.No. Hoppers control (%) Sheath blight control (%) at 14 DAA Grain discoloration disease control (%)
3 DAA 7 DAA 14 DAA
Observed Expected Colby's ratio
T1 98.97 85.64 1.16 95.26 84.92 84.37 88.76
T2 99.13 86.07 1.15 97.83 86.48 88.36 90.24
T3 98.43 85.27 1.15 94.87 85.35 85.76 89.32
T4 99.27 86.51 1.15 97.17 87.12 83.29 86.53
T5 65.38 63.44 1.03 51.39 12.59 81.20 86.35
T6 65.13 64.54 1.01 52.96 14.28 85.32 87.39
T7 63.28 62.48 1.01 50.84 13.28 82.45 86.93
T8 66.74 65.64 1.02 54.12 15.84 80.12 84.12
T9 68.13 67.18 1.01 56.22 25.37 77.32 85.64
T10 69.83 68.17 1.02 56.82 27.43 81.32 87.10
T11 67.44 66.33 1.02 55.32 24.44 78.42 86.33
T12 70.26 69.16 1.02 57.93 27.85 75.88 82.98
T13 98.15 82.82 1.19 90.83 79.73 6.32 4.78
T14 60.73 - - 51.97 29.14 4.92 3.88
T15 56.25 - - 47.46 15.78 6.84 5.32
T16 16.43 - - 10.73 0.96 73.24 83.66
T17 18.94 - - 14.25 1.14 77.64 85.21
T18 14.25 - - 9.84 0.00 74.38 84.43
T19 21.47 - - 15.85 2.18 72.23 80.23
T20 73.87 - - 60.86 31.28 39.88 30.76
T21 72.14 - - 58.48 28.57 76.12 80.17
T22 63.87 - - 54.81 16.38 74.23 82.56
T23 0.00 - - 0.00 0.00 0.00 0.00

Conclusion: In this trial mixed infestation of brown plant hopper (BPH) and white backed plant hopper (WBPH) were observed. All the present compositions (T1 to T4) provide synergistic and residual control of both the species of hoppers up to 14 days. The present composition (T1 to T4) also provides effective control of sheath blight and grain discoloration diseases of rice crop. At last, the Colby's ratio observed was >1 which means strong synergism, when compared with known combinations and market products.

Example 3: Residual control of mango Hoppers.
Crop : Mango
Location : Valsad, Gujarat.
Number of Treatments: 9
Plot size : one tree per treatment.
Crop stage : flowering stage.
Method of application: foliar spray with battery operated backpack sprayer
Water volume : 20 liter per tree
Observation Methods: as per example 1

Composition of Compound A 4%+ Compound B 18%+ Compound C6 12% SC
[T1 of Ex.3]
Chemical Composition Function content (%,w/w)
Compound A Compound A 4.00
Compound B Compound B 18.00
Compound C6 Compound C2 12.00
Polyalkyleneoxide modified trisiloxane super wetting-spreading-penetrating agent 4.00
Octylphenol ethoxylate Dispersing agent 5.00
polyarylphenyl anionic ether sulfate, ammonium salts Dispersing agent 1.25
Bentonite clay Suspending agent 0.50
Polydimethylsiloxane Anti foaming agent 0.30
Sodium benzoate preservative 0.20
Glycerine Anti freezing agent 5.00
Carboxy methyl cellulose Thickener 0.20
Diluent water Solvent 55.80
Total 100.00
active ingredient on 100% purity basis


Storage Stability: Compound A 4%+ Compound B 18%+ Compound C6 12% SC
[T1 of Ex.3]
Laboratory storage stability for 14 days [T1 of Ex.3]
Parameters Specification Initial At 54±2 0C At 0±2 0C
Compound A content (%, w/w) 3.80 to 4.30 4.18 4.16 4.18
Compound B content (%, w/w) 17.10 to 18.90 18.72 18.68 18.71
Compound C6 content (%, w/w) 11.40 to 12.60 12.40 12.37 12.4
Compound A suspensibility (%) 80 98.60 98.10 98.50
Compound B suspensibility (%) 80 98.50 98.30 98.50
Compound C6 suspensibility (%) 80 98.70 98.20 98.45
pH range (1% aq. Suspension) 5.5 to 8.0 7.05 7.15 7.05
Pourability (%) 95 98.20 98.00 98.10
Specific gravity 1.05-1.10 1.07 1.07 1.07
Viscosity at spindle no.62,20 rpm 350-800 cps 530 550 550
Particle size (micron) D50<3, D90<10 2.1,8.5 2.1,8.7 2.1,8.7
Persistent foam ml (after 1 minute) max. 60 Nil nil nil

Room temperature storage stability up to 12 months [T1 of Ex.3]
Parameters Specification 1 month 6 month 12 month
Compound A content (%, w/w) 3.80 to 4.30 4.18 4.16 4.16
Compound B content (%, w/w) 17.10 to 18.90 18.72 18.68 18.68
Compound C6 content (%, w/w) 11.40 to 12.60 12.40 12.37 12.37
Compound A suspensibility (%) 80 98.50 98.50 98.40
Compound B suspensibility (%) 80 98.50 98.50 98.40
Compound C6 suspensibility (%) 80 98.70 98.60 98.60
pH range (1% aq. Suspension) 5.5 to 8.0 7.05 7.05 7.10
Pourability (%) 95 98.20 98.20 98.10
Specific gravity 1.05-1.10 1.07 1.07 1.07
Viscosity at spindle no. 62, 20 rpm 350-800 cps 530 530 535
Particle size (micron) D50<3, D90<10 2.1,8.5 2.1,8.5 2.1,8.6
Persistent foam in ml (after 1 minute) max. 60 Nil nil nil
The composition of Compound A 4%+ Compound B 18%+ Compound C6 12% SC meets the all in house specifications for storage stability studies in laboratory (at 54±2 C & At 0±2 C for 14 days) and room temperature (for 12 months).


Manufacturing process for 100 kg batch of Compound A 4%+ Compound B 18%+ Compound C6 12% WDG [T1 of Ex. 3]
Step 1 Preparation of 2% Gum Solution: Charge 2.0 kg carboxy methyl cellulose and 2.0 kg 1,2-benzisothiazoline-3-one (2.0 kg) into 96.0 kg water and homogenize. It should be made 12 to 18 hours prior to use.
Step 2 Charge 45.80 kg of DM water and 5.0 kg Glycerine into designated vessel and mix thoroughly.
Step 3 Add 5.0 kg Octylphenol ethoxylate, 1.25 kg polyarylphenyl anionic ether sulfate, ammonium salts and 0.5 kg Bentonite clay into the vessel having water and homogenise the contents for 45 to 60 minutes using high shear homogeniser.
Step 4 Then add 4 kg Compound A tech., 18 kg Compound B tech. and 12 kg Compound C6 tech. to this premix slowly and homogenised to get uniform slurry ready for grinding.
Step 5 Before grinding half the quantity of Polydimethylsiloxane (0.15 kg) was added and then material was subjected to grinding in Dyno mill till desired particle size was achieved.
Step 6 Add remaining Polydimethyl siloxane (0.15 kg) antifoam was added after grinding process completes and before sampling for in process analysis.
Step 7 Finally add 10.0 kg of 2% Xanthum gum solution and 4.0 kg polyalkyleneoxide modified trisiloxane to this formulation and homogenized for 30 minutes.
Step 8 Now this was sent for final formulation to QC for quality check.


Table 3: Treatment details
Sr.no. Treatment details Dose (gram actives per 1000-liter water)
T1 Compound A 4%+ Compound B 18%+ Compound C6 12% SC 30+135+90
T2 Compound A 4%+ Compound B 18%+ Compound C7 10% SC 30+135+75
T3 Compound A 4%+ Compound B 18%+ Compound C8 8% SC 30+135+60
T4 Compound A 10.6% (10% w/v) SC 30
T5 Compound B 50% WG 135
T6 Compound C6 24% SC 90
T7 Compound C7 33.3% FS 75
T8 Compound C8 3% L 60
T9 Untreated Check (UTC) -

T1 to T3 are present composition.

Table 4: Residual control of Mango Hoppers and powdery mildew
Sr.no. Mango Hopper control (%) Powdery mildew disease control (%)
7 DAA 14 DAA 14 DAA
Observed Expected Colby's ratio Observed Expected Colby's ratio Observed Expected Colby's ratio
T1 98.95 93.89 1.05 88.93 73.79 1.21 75.93 64.63 1.17
T2 97.28 93.56 1.04 85.68 71.69 1.20 87.25 79.70 1.09
T3 96.97 93.22 1.04 81.26 67.93 1.20 83.18 70.18 1.19
T4 46.82 - - 25.85 - - 8.53 - -
T5 67.85 - - 42.47 - - 10.24 - -
T6 64.26 - - 38.56 - - 56.92 - -
T7 62.35 - - 33.63 - - 75.27 - -
T8 60.35 24.83 63.68
T9 0.00 - - 0.00 - - 0.00 - -

Conclusion: All the present compositions (T1 to T3) provide synergistic and residual control of mango hoppers and powdery mildew diseases up to 14 days. At last, the Colby's ratio observed was >1 which means strong synergism, when compared with known combinations and market products.
The process for preparing the combination of insecticidal and fungicidal composition can be modified accordingly by any person skilled in the art based on the knowledge of the manufacturing the formulation. However, all such variation and modification is still covered by the scope of present invention.
Application to the seeds is carried out before sowing, either directly on the seeds or after having pregerminated the latter. Suitable application methods include inter alia soil treatment, seed treatment, in furrow application, and foliar application. Soil treatment methods include drenching the soil, drip irrigation (drip application onto the soil), dipping roots, tubers or bulbs, or soil injection. Seed treatment techniques include seed dressing, seed coating, seed dusting, seed soaking, and seed pelleting. In furrow applications typically include the steps of making a furrow in cultivated land, seeding the furrow with seeds, applying the pesticidally active composition to the furrow, and closing the furrow. Foliar application refers to the application of the pesticidally active composition to plant foliage, e.g. through spray equipment.
The rates of application vary within wide limits and depend on the nature of the soil, the method of application, the crop plant, the pest to be controlled, the prevailing climatic conditions, and other factors governed by the method of application, the time of application and the target crop.
The present invention is suitable for use in protecting crops, plants, plant propagation materials, such as seeds, or sailor water, in which the plants are growing, from attack or infestation by animal pests. Therefore, the present invention also relates to a plant protection method, which comprises contacting crops, plants, plant propagation materials, such as seeds, or soil or water, in which the plants are growing, to be protected from attack or infestation by animal pests, with a insecticidally effective amount of the present invention.
The present invention is also suitable for use in combating or controlling animal pests. Therefore, the present invention also relates to a method of combating or controlling animal pests, which comprises contacting the animal pests, their habitat, breeding ground, or food supply, or the crops, plants, plant propagation materials, such as seeds, or soil, or the area, material or environment in which the animal pests grow, with an insecticidally effective amount of the present invention.
The lists of crops on which the insecticidal/fungicidal composition of the present invention is used include, but not limited to GMO (Genetically Modified Organism) and Non GMO traits, hybrids and conventional varieties of Cotton (Gossypium spp.), Paddy/Rice (Oryza sativa), Wheat (Triticumaestavum), Barley (Hordeum vulgare), Maize (Zea mays), Sorghum (Sorghum bicolor), Oat (Avena sativa), Pearl millet (Pennisetum glaucum),Sugarcane (Saccharum officinarum), Sugarbeet (Beta vulgaris), Soybean (Glycin max), Groundnut/Peanut (Arachis hypogaea), Sunflower (Helianthus annuus), Mustard (Brassica juncea), Rape seed (Brassica napus), Sesame (Sesamum indicum), Green gram (Vigna radiata), Black gram (Vigna mungo), Chickpea (Cicer aritinum), Cowpea (Vigna unguiculata), Redgram (Cajanus cajan), Frenchbean (Phaseolus vulgaris), Indian bean (Lablab purpureus), Horse gram (Macrotyloma uniflorum), Field pea (Pisum sativum), Cluster bean (Cyamopsis tetragonoloba), Lentils (Lens culinaris), Brinjal (Solanum melongena), Cabbage (Brassica oleracea var. capitata), Cauliflower (Brassica oleracea var. botrytis), Okra (Abelmoschus esculentus), Onion (Allium cepa L.),Tomato (Solanum lycopersicun), Potato (Solanum tuberosum), Sweet potato (Ipomoea batatas), Chilly (Capsicum annum), Bell pepper (Capsicum annum), Garlic (Allium sativum), Cucumber (Cucumis sativus), Muskmelons (Cucumis melo), Watermelon (Citrullus lanatus), Bottle gourd (Lagenaria siceraria), Bitter gourd (Momordica charantia), Radish (Raphanus sativus), Carrot (Dacus carota subsp. sativus), Turnip (Brassica rapa rapa), Apple (Melus domestica), Banana (Musa spp.), Citrus groups (Citrus spp.), Grape (Vitis vinifera), Guava (Psidium guajava), Mango (Mangifera indica), Papaya (Carica papaya), Pineapple (Ananas comosus), Pomegranate (Punica granatum), Sapota (Manilkara zapota), Tea (Camellia sinensis), Coffea (Coffea Arabica), Turmeric (Curcuma longa), Ginger (Zingiber officinale), Cumin (Cuminum cyminum), Black Pepper (Piper nigrum), Mentha ( Mentha spp.), Rose (Rosa spp.), Jasmine (Jasminum spp.), Marigold ( Tagetes spp.), Common daisy (Bellis perennis), Dahlia (Dahlia hortnesis), Gerbera ( Gerbera jamesonii), Carnation (Dianthus caryophyllus).

Other useful plants include turf grass for example in golf-courses, lawns, parks and roadsides, or grown commercially for sod, and ornamental plants such as flowers or bushes.
The present invention will be used to control the following insects-pests and diseases. The major insects pests arerice leafhopper/green leaf hopper (GLH) Nephotettix nigropictus, rice brown plant hopper (BPH) Nilaparvata lugen, rice backed plant hopper (WBPH) Sogatella furcifera, bean aphid Aphis fabae, black citrus aphid Toxoptera aurantii, citrus black scale Saissetia oleae, cabbage aphid Brevicoryne brassicae, Lipaphis erysimi, citrus red scale Aonidiella aurantii, yellow scale Aonidiella citrine, citrus mealybug Planococcus citri, corn leaf aphid Rhopalosiphum maidis, aphid Aphis gossypii, jassid Amrasca biguttula biguttla, mealy bug Planococcus spp. And Pseudococcus spp., cotton stainer Dysdercus suturellus, whitefly Bemisia tabaci, cowpea aphid Aphis crassivora, grain aphid Sitobion avenae, golden glow aphid Uroleucon spp., grape mealybug Pseudococcus maritimus, green peach aphid Myzus persicae, greenhouse whitefly Trialeurodes vaporariorum, papaya mealy bug Pracoccus marginatus, pea aphid Acyrthosiphon pisum, sugarcane mealybug Saccharicoccus sacchari, potato aphid Myzus persicae, potato leaf hopper Empoasca fabae, cotton whitefly Bemisia tabaci, tarnished plant bug Lygus lineolaris, wooly apple aphid Eriosoma lanigerum, mango hopper Amritodus atkinsoni, Idioscopus spp., paddy stem borer Scirpophaga excerptallis, Scirpophaga incertulas, Scirpophaga innotata, wheat stem borer Sesamia inferens, rice water weevil Lissorhoptrusoryzophilus.
The present invention will be used to control various diseases. The diseases controlled are sheath blight (Rhizoctonia solani), Black kernel Curvularialunata,Blast (leaf, neck [rotten neck], nodal and collar) Pyricularia grisea=P.oryzae,Brown spot Cochliobolusmiyabeanus,Crown sheath rot Gaeumannomycesgraminis,Downy mildew Sclerophthoramacrospora, Eyespot Drechslera gigantean,False smut Ustilaginoidea virens,Kernel smut Tilletiabarclayana=Neovossia horrid,Leaf smutEntyloma oryzae,Leaf scald Microdochium oryzae,Narrow brown leaf spot Cercosporajanseana,Grain discoloration (kernel spotting) Damage by many fungi including Cochliobolusmiyabeanus, Curvularia spp., Fusarium spp., Microdochium oryzae, Sarocladium oryzae, Root rots Fusarium spp., Pythium spp., P. dissotocum, P. spinosum,Seedling blight Cochliobolusmiyabeanus, Curvularia spp., Fusarium spp., Rhizoctonia solani, Sclerotium rolfsii,Sheath blight Thanatephoruscucumeris(anamorph: Rhizoctonia solani), Sheath rot Sarocladium oryzae = Acrocylindrium oryzae, Sheath spot Rhizoctonia oryzae, Stackburn (Alternaria leaf spot) Alternaria padwickii, Stem rot Magnaporthesalvinii= Sclerotium oryzae, Water-mold (seed-rot and seedling disease) Achlyaconspicua, A. klebsiana, Fusarium spp., Pythium spp., P. dissotocum, P. spinosum.
The present invention has been described with reference to specific embodiment which is merely illustrative and not intended to limit the scope of the invention as defined in the present complete specification.
, Claims:We Claim:
1. A combination of insecticidal and fungicidal agrochemical composition comprising:
A) Compound A: 2 to 8 w/w% of 4-oxo-1-(pyrimidin-5-ylmethyl)-3-[3-(trifluoromethyl)phenyl]pyrido[1,2-a]pyrimidin-1-ium-2-olate;
B) Compound B: 12 to 40 w/w% of 6-methyl-4-[(E)-pyridin-3-ylmethylideneamino]-2,5-dihydro-1,2,4-triazin-3-one;
C) Compound C: 5 to 25 w/w% of at least one compound selected from group of fungicide and agrochemically acceptable excipients.

2. The combination of insecticidal and fungicidal agrochemical composition as claimed in claim 1, wherein the fungicides for compound C is selected from the group consisting of

C1, methyl N-[2-[[1-(4-chlorophenyl)pyrazol-3-yl]oxymethyl]phenyl]-N-methoxycarbamate,

C2, methyl (E)-2-[2-[6-(2-cyanophenoxy)pyrimidin-4-yl]oxyphenyl]-3-methoxyprop-2-enoate,

C3, methyl (2Z)-2-methoxyimino-2-[2-[[(E)-1-[3-(trifluoromethyl)phenyl]ethylideneamino]oxymethyl]phenyl]acetate,

C4, methyl (E)-3-methoxy-2-[2-[[6-(trifluoromethyl)pyridin-2-yl]oxymethyl]phenyl]prop-2-enoate,

C5, methyl (2E)-2-methoxyimino-2-[2-[(2-methylphenoxy)methyl]phenyl]acetate,
C6, N-[2,6-dibromo-4-(trifluoromethoxy)phenyl]-2-methyl-4-(trifluoromethyl)-1,3-thiazole-5-carboxamide,

C7, 3-(difluoromethyl)-1-methyl-N-[2-(3,4,5-trifluorophenyl)phenyl]pyrazole-4-carboxamide or

C8, (2R,3R,4S,5S,6R)-2-[(1R,2R,3S,4S,6R)-2,3-dihydroxy-6-(hydroxymethyl)-4-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino]cyclohexyl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol.

3. The combination of insecticidal and fungicidal agrochemical composition as claimed in claim 1, wherein the agrochemically acceptable excipients are selected from the group consisting of wetting agent(s), wetting-spreading-penetrating agent(s), dispersing agent(s), suspending agent(s), antifoaming agent(s), anti-freezing agent(s), preservative(s), thickener(s), solvent(s) and carrier(s).

4. The combination of insecticidal and fungicidal agrochemical composition as claimed in claim 1, wherein the composition is in the form of Capsule suspension (CS), Dispersible concentrate (DC), Dustable powder (DP), Powder for dry seed treatment (DS), Emulsifiable concentrate (EC), Emulsifiable granule (EG), Emulsion water-in-oil (EO), Emulsifiable powder (EP), Emulsion for seed treatment (ES), Emulsion oil-in-water (EW), Flowable concentrate for seed treatment (FS), Granules (GR), Micro-emulsion (ME), Oil-dispersion (OD), Oil miscible flowable concentrate (OF), Oil miscible liquid (OL), Oil dispersible powder (OP), Suspension concentrate (SC), Suspension concentrate for direct application (SD), Suspo-emulsion (SE), Water soluble granule (SG), Soluble concentrate (SL), Spreading oil (SO), Water soluble powder (SP), Water soluble tablet (ST), Ultra-low volume (ULV) suspension, Tablet (TB), Ultra-low volume (ULV) liquid, Water dispersible granules (WDG/WG), Wettable powder (WP), Water dispersible powder for slurry seed treatment (WS), Water dispersible tablet (WT), a mixed formulation of CS and SC (ZC) or A mixed formulation of CS and SE (ZE), a mixed formulation of CS and EW (ZW).

5. The combination of insecticidal and fungicidal agrochemical composition as claimed in claim 1, wherein the composition is preferably in the form of a Suspension concentrate (SC) and Water dispersible granules (WDG/WG).

6. The combination of insecticidal and fungicidal agrochemical composition as claimed in claim 3, wherein the wetting-spreading-penetrating agent(s) for suspension concentrate (SC) is selected from trisiloxane ethoxylate, heptamethyl trisiloxane, modified form includes polyalkyleneoxide modified heptamethyl trisiloxane, polyether modified polysiloxane, polyalkyleneoxide modified trisiloxane, polyalkyleneoxide modified polydimethylsiloxane, may be liquid or powder form and mixture thereof.

7. The combination of insecticidal and fungicidal agrochemical composition as claimed in claim 3, wherein the dispersing agent(s) for suspension concentrate (SC) is selected from Octylphenol ethoxylate, polyarylphenyl anionic ether sulfate, ammonium salts, Naphthalenesulfonic acid, sodium salt condensate with formaldehyde, alkylated naphthalene sulfonate, sodium salt, sodium salt of naphthalene sulfonate condensate, sodium ligno sulfonate, sodium polycarboxylate, EO/PO based copolymer, phenol sulfonate, sodium methyl oleoyl taurate, styrene acrylic acid copolymer, propylene oxide-ethylene oxide-copolymer, polyethylene glycol 2,4,6-tristyrylphenyl ether, tristyrylphenol-polyglycol ether-phosphate, tristyrylphenole with 16 moles EO, tristyrylphenol-polyglycol ether-phosphate, oleyl-polyglycol ether with ethylene oxide, tallow fatty amine polyethylene oxide, nonylphenol polyglycol ether with 9-10 moles ethylene oxide and mixture thereof.

8. The combination of insecticidal and fungicidal agrochemical composition as claimed in claim 3, wherein the suspending agent(s) for suspension concentrate (SC) is selected from aluminum magnesium silicate, bentonite clay, silica, attapulgite clay and mixture thereof.

9. The combination of insecticidal and fungicidal agrochemical composition as claimed in claim 3, wherein the antifoaming agent(s) for suspension concentrate (SC) is selected from silicone antifoam emulsion, dimethyl siloxane, polydimethyl siloxane, vegetable oil based antifoam, tallow based fatty acids and mixture thereof.

10. The combination of insecticidal and fungicidal agrochemical composition as claimed in claim 3, wherein the preservative(s) for suspension concentrate (SC) is selected from 1,2-benzisothiazolin-3(2H)-one, sodium salt, sodium benzoate, 2-bromo-2-nitropropane-1,3-diol, formaldehyde, sodium o-phenyl phenate, 5-chloro-2-methyl-4-isothiazolin-3-one & 2-methyl-4-isothiazolin-3-one or mixture thereof.

11. The combination of insecticidal and fungicidal agrochemical composition as claimed in claim 3, wherein the antifreezing agent(s) for suspension concentrate (SC) is selected from ethylene glycol, propane diols, glycerin or the urea, glycol (monoethylene glycol, diethylene glycol, polypropylene glycol, polyethylene glycol), glycerin, urea, magnesium sulfate heptahydrate, sodium chloride etc and mixtures thereof.

12. The combination of insecticidal and fungicidal agrochemical composition as claimed in claim 3, wherein the thickener(s) for suspension concentrate (SC) is selected from xanthan gum, PVK, carboxymethyl celluloses, polyvinyl alcohols, gelatin, sodium carboxymethylcellulose, hydroxyethyl cellulose, sodium polyacrylate, modified starch, acacia gum and mixtures thereof.

13. The combination of insecticidal and fungicidal agrochemical composition as claimed in claim 3, wherein the solvent(s) for suspension concentrate (SC) is selected from diluent water.


14. The combination of insecticidal and fungicidal agrochemical composition as claimed in claim 3, wherein the dispersing agent(s) for Wettable Granule/Water Dispersible Granule (WG/WDG) is selected from alkylnaphthalene sulfonate sodium salt, sodium polycarboxylate, naphthalenesulfonic acid, sodium salt condensates with formaldehyde, polyalcoxylated alkylphenol, sodium polycarboxylate, naphthalenesulfonic acid formaldehyde condensate, methylnaphthalene-formaldehyde-condensate sodium salt, naphthalene condensates, polyacrylates copolymer and phosphate esters, calcium lignosulfonate, sodium lignosulfonates, lignin sulfonate sodium salt, Sodium Methyl Oleoyl Taurate and mixtures thereof.

15. The combination of insecticidal and fungicidal agrochemical composition as claimed in claim 3, wherein the wetting agent(s) for Wettable Granule/Water Dispersible Granule (WG/WDG) is selected from sodium N-methyl-N-oleoyl taurate, alkylated naphthalene sulfonate, sodium salt, mixture of isomers of dibutylnaphthalene sulphonic acid sodium salt, sodium isopropylnaphthalenesulphonate,Sodium isobutyl naphthalene sulfonate, sodium Lauryl sulfate, dioctyl sulfate, alkyl naphthalene sulfonates, phosphate esters, sulphosuccinates and non-ionic such as tridecyl alcohol ethoxylate, alkyl or alkaryl sulfonates such as alkylbenzene sulfonates, alpha olefin sulfonate and alkyl naphthalene sulfonates, ethoxylated or non-ethoxylated alkyl or alkaryl carboxylates, alkyl or alkaryl phosphate esters, alkyl polysaccharide, di or mono alkyl sulfosuccinate derivatives, alpha olefin sulfonates, alkyl naphthalene sulfonates, dialkyl sulphosuccinates, butyl, dibutyl, isopropyl and di-isopropyl naphthalene sulfonate salts, C12 alkyl benzene sulfonate or C10-C16 alkyl benzene sulfonate, organosilicons surfactants includes trisiloxane ethoxylate, polydimethylsiloxane, polyoxyethylene methyl polysiloxane, polyoxyalkylene methyl polysiloxane, polyether polymethyl siloxane copolymer, trisiloxaneheptamethyl, Polyalkyleneoxide modified heptamethyl trisiloxane, polyether modified polysiloxane, may or may not be in modified form, may be liquid or powder form or mixtures thereof.

16. The combination of insecticidal and fungicidal agrochemical composition as claimed in claim 3, wherein the antifoaming agent(s) for Wettable Granule/Water Dispersible Granule (WG/WDG) is selected from polydimethylsiloxane.

17. The combination of insecticidal and fungicidal agrochemical composition as claimed in claim 3 wherein the carrier(s) for Wettable Granule/Water Dispersible Granule (WG/WDG) is selected from china clay, silica, lactose anhydrous, ammonium sulfate, sodium sulfate anhydrous, corn starch, urea,EDTA, urea formaldehyde resin, diatomaceous earth, kaolin, bentonite, kieselguhr, fuller's earth, attapulgite clay,bole, loess, talc, chalk, dolomite, limestone, lime, calcium carbonate, powdered magnesia, magnesium oxide, magnesium sulphate, sodium chloride, gypsum, calcium sulphate, pyrophyllite, silicates and silica gels; fertilizers such as, for example, ammonium sulphate, ammonium phosphate, ammonium nitrate and urea; natural products of vegetable origin such as, for example, grain meals and flours, bark meals, wood meals, nutshell meals and cellulosic powders; and synthetic polymeric materials such as, for example, ground or powdered plastics and resins, bentonites, zeolites, titanium dioxide, iron oxides and hydroxides, aluminium oxides and hydroxides, or organic materials such as bagasse, charcoal, or synthetic organic polymers or mixtures thereof.

Dated this on 29th October, 2024

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